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Title: Polycystic kidney disease : new knowledge and future promises
Authors: Foo, Jia Nee
Xia, Yun
Keywords: Science::Medicine
Issue Date: 2019
Source: Foo, J. N., & Xia, Y. (2019). Polycystic kidney disease : new knowledge and future promises. Current Opinion in Genetics & Development, 56, 69-75. doi:10.1016/j.gde.2019.06.007
Journal: Current Opinion in Genetics & Development
Abstract: Polycystic kidney disease (PKD) is one of the most common genetic kidney diseases, characterized by the formation of fluid-filled renal cysts, which eventually lead to end-stage renal disease. Despite several decades of investigation, explicit molecular and cellular mechanisms underpinning renal cyst formation have been unresolved until recently, severely hampering the development of effective therapeutic approaches. Currently, most PKD therapies have been developed for limiting disease complications, such as hypertension. Although Tolvaptan has been approved for treating PKD in few countries, the associated hepatic toxicity remains a major concern. In this Review, we will discuss recent advances in PKD research, covering aspects ranging from newly identified genetic/epigenetic causes, increment in mechanistic interpretation, novel therapeutic targets, to the promises offered by emerging stem cell technologies.
ISSN: 0959-437X
DOI: 10.1016/j.gde.2019.06.007
Rights: © 2019 Elsevier Ltd. All rights reserved. This paper was published in Current Opinion in Genetics & Development and is made available with permission of Elsevier Ltd.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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