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|Title:||No association of DNM3 with age of onset in Asian Parkinson's disease||Authors:||Foo, Jia Nee
Tan, Louis C.
|Keywords:||Science::Biological sciences::Genetics||Issue Date:||2018||Source:||Foo, J. N., Tan, L. C., Au, W.-L., Prakash, K.-M., Liu, J., & Tan, E.-K. (2019). No association of DNM3 with age of onset in Asian Parkinson's disease. European Journal of Neurology, 26(5), 827-829. doi:10.1111/ene.13785||Journal:||European Journal of Neurology||Abstract:||Background: Genetic variability in DNM3 have been shown to modify age of onset of Parkinson’s disease (PD) among LRRK2 Gly2019Ser carriers in North African Arab-Berber populations. In Asian populations, the Gly2019Ser mutation is rare or absent but two other LRRK2 variants Gly2385Arg and Arg1628PPro increase PD risk. We aim to determine if the DNM3 locus is associated with age of PD onset in both carriers and non-carriers of LRRK2 risk variants in Asians. Methods: We analyzed the association of DNM3 rs2421947 genotypes with age of PD onset in 3,645 Chinese samples, of which 369 carry at least one of two Asian LRRK2 risk variants. Results: DNM3 rs2421947 genotypes were not associated with PD age of onset in Chinese samples. We observed no heterogeneity in the effect of rs2421947 between the Asian LRRK2 risk variant carriers and non-carriers. Conclusions: DNM3 rs2421947 is not associated with age of PD onset in LRRK2 risk variant carriers and non-carriers in Chinese. Further studies in other Asian populations will be of interest.||URI:||https://hdl.handle.net/10356/141196||ISSN:||1351-5101||DOI:||10.1111/ene.13785||Rights:||© 2018 European Academy of Neurology. All rights reserved. This paper was published in European Journal of Neurology and is made available with permission of European Academy of Neurology.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
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