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Title: ITPKB and ZNF184 are associated with Parkinson’s disease risk in East Asians
Authors: Chew, Elaine Guo Yan
Tan, Louis C. S.
Au, Wing-Lok
Prakash, Kumar-M.
Liu, Jianjun
Foo, Jia Nee
Tan, Eng-King
Keywords: Science::Biological sciences::Genetics
Issue Date: 2019
Source: Chew, E. G. Y., Tan, L. C. S., Au, W.-L., Prakash, K.-M., Liu, J., Foo, J. N., & Tan, E.-K. (2020). ITPKB and ZNF184 are associated with Parkinson's disease risk in East Asians. Neurobiology of Aging, 86, 201.e15-201.e17. doi:10.1016/j.neurobiolaging.2019.01.026
Journal: Neurobiology of Aging
Abstract: A recent meta-analysis of Parkinson's disease (PD) genome-wide association studies has identified 17 novel risk loci in the European population. We aim to assess if these reported novel risk loci are similarly implicated in PD risk within the East Asian population by analyzing the reported risk single nucleotide polymorphism or proxy single nucleotide polymorphism in 14,006 East Asian samples (779 patients and 13,227 controls). We found that 9 of the 17 reported novel PD risk loci showed very similar effects in Europeans and East Asians (I2 = 0 to 10.7%), of which 2 loci ITPKB and ZNF184 were significantly associated with PD in our samples. Two of the reported risk loci, ANK2/CAMK2D and CTSB, were non-polymorphic in East Asians and therefore not implicated in PD risk in the East Asian population. Given the small effect sizes of these risk loci, further validation is needed in additional Asian samples.
ISSN: 0197-4580
DOI: 10.1016/j.neurobiolaging.2019.01.026
Rights: © 2019 Elsevier Inc. All rights reserved. This paper was published in Neurobiology of Aging and is made available with permission of Elsevier Inc.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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