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Title: The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines
Authors: Bates, Roderick Wayland
Ko, Weiting
Barát, Viktor
Keywords: Science::Chemistry
Issue Date: 2020
Source: Bates, R. W., Ko, W., & Barát, V. (2020). The endo-aza-Michael addition in the synthesis of piperidines and pyrrolidines. Organic & Biomolecular Chemistry, 18(5), 810-829. doi:10.1039/C9OB02388G
Journal: Organic & Biomolecular Chemistry
Abstract: Intramolecular endo-aza-Michael additions are categorised in various ways. Firstly whether they are single or double reactions, secondly whether they are endo- or exo-activated (or both), thirdly whether the Michael acceptor is an alkene or an alkyne, and finally whether the product is a six or a five membered ring. Reactions in the various categories are illustrated by syntheses of piperidines and pyrrolidines, including a range of natural products. The question of the stereochemical outcome and whether it is understood is discussed.
ISSN: 1477-0520
DOI: 10.1039/C9OB02388G
Rights: © 2020 The Royal Society of Chemistry. All rights reserved. This paper was published in Organic & Biomolecular Chemistry and is made available with permission of The Royal Society of Chemistry.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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