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https://hdl.handle.net/10356/141341
Title: | Large 3‐Mb deletions at 22q11.2 locus in Parkinson's disease and schizophrenia | Authors: | Foo, Jia Nee Lee, Jimmy Tan, Louis C. Liu, Jianjun Tan, Eng-King |
Keywords: | Science::Biological sciences::Genetics | Issue Date: | 2016 | Source: | Foo, J. N., Lee, J., Tan, L. C., Liu, J., & Tan, E.-K. (2016). Large 3‐Mb deletions at 22q11.2 locus in Parkinson's disease and schizophrenia. Movement Disorders, 31(12), 1924-1925. doi:10.1002/mds.26822 | Journal: | Movement Disorders | Abstract: | 22q11.2 microdeletions are among the most common deletions found in humans. Whereas most cases present in early childhood, a large fraction remain undetected into adulthood. Adult carriers are at increased risk of developing schizophrenia.1 More recently, these deletions have also been associated with Parkinson's disease (PD). Butcher and colleagues reported that a small proportion of 22q11.2 deletion carriers aged above 35 years have developed early‐onset PD,2 although the diagnosis was delayed in individuals undergoing antipsychotic treatment for schizophrenia. Subsequently, Mok and colleagues screened for the deletion in 9,387 PD cases and 13,863 controls3 and identified 8 carriers among cases, but none in controls. This deletion was particularly enriched among early‐onset cases. Most of these studies were conducted in samples of European ancestry, but the prevalence in Asian samples is unknown. | URI: | https://hdl.handle.net/10356/141341 | ISSN: | 0885-3185 | DOI: | 10.1002/mds.26822 | Schools: | Lee Kong Chian School of Medicine (LKCMedicine) | Rights: | © 2016 International Parkinson and Movement Disorder Society. All rights reserved. This paper was published by Wiley Online Library in Movement Disorders and is made available with permission of International Parkinson and Movement Disorder Society. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | LKCMedicine Journal Articles |
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