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Title: Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan-silica hybrid sponge in a porcine model
Authors: Park, Ji-Ung
Jeong, Seol-Ha
Song, Eun-Ho
Song, Juha
Kim, Hyoun-Ee
Kim, Sukwha
Keywords: Engineering::Chemical engineering
Issue Date: 2018
Source: Park, J.-U., Jeong, S.-H., Song, E.-H., Song, J., Kim, H.-E., & Kim, S. (2018). Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan-silica hybrid sponge in a porcine model. Journal of Biomaterials Applications, 32(8), 1011-1023. doi:10.1177/0885328217751246
Journal: Journal of Biomaterials Applications
Abstract: In this study, we evaluated the surface characterization of a novel chitosan-silica hybridized membrane and highlighted the substantial role of silica in the wound environment. The chemical coupling of chitosan and silica resulted in a more condensed network compared with pure chitosan, which was eventually able to stably maintain its framework, particularly in the wet state. In addition, we closely observed the wound-healing process along with the surface interaction between chitosan-silica and the wound site using large-surface-area wounds in a porcine model. Our evidence indicates that chitosan-silica exerts a synergetic effect of both materials to promote a remarkable wound-healing process. In particular, the silica in chitosan-silica accelerated wound closure including wound contraction, and re-epithelialization via enhancement of cell recruitment, epidermal maturity, neovascularization, and granulation tissue formation compared with pure chitosan and other commercial dressing materials. This advanced wound dressing material may lead to effective treatment for problematic cutaneous wounds and can be further applied for human skin regeneration.
ISSN: 0885-3282
DOI: 10.1177/0885328217751246
Rights: © 2018 The Author(s). All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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