Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/141596
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dc.contributor.authorJiang, Yuen_US
dc.contributor.authorLiu, Xuen_US
dc.contributor.authorDang, Tran Chienen_US
dc.contributor.authorHuang, Xiweien_US
dc.contributor.authorFeng, Haoen_US
dc.contributor.authorZhang, Qingen_US
dc.contributor.authorYu, Haoen_US
dc.date.accessioned2020-06-09T06:38:47Z-
dc.date.available2020-06-09T06:38:47Z-
dc.date.issued2018-
dc.identifier.citationJiang, Y., Liu, X., Dang, T. C., Huang, X., Feng, H., Zhang, Q., & Yu, H. (2018). A high-sensitivity potentiometric 65-nm CMOS ISFET sensor for rapid E. coli screening. IEEE Transactions on Biomedical Circuits and Systems, 12(2), 402-415. doi:10.1109/TBCAS.2018.2793861en_US
dc.identifier.issn1932-4545en_US
dc.identifier.urihttps://hdl.handle.net/10356/141596-
dc.description.abstractFoodborne bacteria, inducing outbreaks of infection or poisoning, have posed great threats to food safety. Potentiometric sensors can identify bacteria levels in food by measuring medium's pH changes. However, most of these sensors face the limitation of low sensitivity and high cost. In this paper, we developed a high-sensitivity ion-sensitive field-effect transistor sensor. It is small sized, cost-efficient, and can be massively fabricated in a standard 65-nm complementary metal-oxide-semiconductor process. A subthreshold pH-to-time-to-voltage conversion scheme was proposed to improve the sensitivity. Furthermore, design parameters, such as chemical sensing area, transistor size, and discharging time, were optimized to enhance the performance. The intrinsic sensitivity of passivation membrane was calculated as 33.2 mV/pH. It was amplified to 123.8 mV/pH with a 0.01-pH resolution, which greatly exceeded 6.3 mV/pH observed in a traditional source-follower based readout structure. The sensing system was applied to Escherichia coli (E. coli) detection with densities ranging from 14 to 140 cfu/mL. Compared to the conventional direct plate counting method (24 h), more efficient sixfold smaller screening time (4 h) was achieved to differentiate samples' E. coli levels. The demonstrated portable, time-saving, and low-cost prescreen system has great potential for food safety detection.en_US
dc.language.isoenen_US
dc.relation.ispartofIEEE Transactions on Biomedical Circuits and Systemsen_US
dc.rights© 2018 IEEE. All rights reserved.en_US
dc.subjectEngineering::Electrical and electronic engineeringen_US
dc.titleA high-sensitivity potentiometric 65-nm CMOS ISFET sensor for rapid E. coli screeningen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen_US
dc.contributor.schoolInterdisciplinary Graduate School (IGS)en_US
dc.contributor.organizationCNRS International NTU THALES Research Allianceen_US
dc.contributor.researchResearch Techno Plazaen_US
dc.identifier.doi10.1109/TBCAS.2018.2793861-
dc.identifier.pmid29570066-
dc.identifier.scopus2-s2.0-85043486082-
dc.identifier.issue2en_US
dc.identifier.volume12en_US
dc.identifier.spage402en_US
dc.identifier.epage415en_US
dc.subject.keywordsE. colien_US
dc.subject.keywordsFood Safetyen_US
item.fulltextNo Fulltext-
item.grantfulltextnone-
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