Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/141925
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dc.contributor.authorChoy, Chiaw Yeeen_US
dc.contributor.authorAng, Li Weien_US
dc.contributor.authorNg, Oon Teken_US
dc.contributor.authorLeo, Yee Sinen_US
dc.contributor.authorWong, Chen Seongen_US
dc.date.accessioned2020-06-12T00:45:21Z-
dc.date.available2020-06-12T00:45:21Z-
dc.date.issued2019-
dc.identifier.citationChoy, C. Y., Ang, L. W., Ng, O. T., Leo, Y. S., & Wong, C. S. (2019). Factors associated with hepatitis B and C co-Infection among HIV-infected patients in Singapore, 2006 – 2017. Tropical Medicine and Infectious Disease, 4(2), 87-. doi:10.3390/tropicalmed4020087en_US
dc.identifier.issn2414-6366en_US
dc.identifier.urihttps://hdl.handle.net/10356/141925-
dc.description.abstractCo-infection of hepatitis B virus (HBV) and hepatitis C virus (HCV) with human immunodeficiency virus (HIV) is associated with increased risk of hepatic complications and mortality. A retrospective study to estimate the proportion of HBV and HCV co-infections in Singapore was conducted using a clinical database. We included 3065 patients who were seen under the Clinical HIV Programme at the largest referral centre for HIV care between 2006 and 2017 and were tested for both HBV and HCV. Factors associated with HIV-HBV and HIV-HCV co-infections were determined using logistic regressions. The majority (86.3%) of HIV-infected patients were mono-infected, while 7.2% were co-infected with HBV, 6.0% with HCV, and 0.5% were co-infected with both HBV and HCV. The most common HCV genotype was GT1 (63%). Factors significantly associated with HBV co-infection in the multivariable model were: Aged 30–49 years and 50–69 years at HIV diagnosis, male gender, and HIV transmission through intravenous drug use (IDU). Independent factors associated with HCV co-infection were: Malay ethnicity, HIV transmission through IDU, and HIV diagnosis between 2006 and 2008. Behavioural risk factors such as IDU, as well as epidemiologic differences associated with co-infection, should inform further studies and interventions aimed at reducing viral hepatitis infection among HIV-infected individuals.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofTropical Medicine and Infectious Diseaseen_US
dc.rights© 2019 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectScience::Medicineen_US
dc.titleFactors associated with hepatitis B and C co-Infection among HIV-infected patients in Singapore, 2006 – 2017en_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.identifier.doi10.3390/tropicalmed4020087-
dc.description.versionPublished versionen_US
dc.identifier.pmid31137801-
dc.identifier.scopus2-s2.0-85072172897-
dc.identifier.issue2en_US
dc.identifier.volume4en_US
dc.subject.keywordsHIVen_US
dc.subject.keywordsHepatitisen_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:LKCMedicine Journal Articles

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