Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/141952
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dc.contributor.authorWong, Yoke-Rungen_US
dc.contributor.authorPang, Xinen_US
dc.contributor.authorLim, Zeus Yiweien_US
dc.contributor.authorDu, Hejunen_US
dc.contributor.authorTay, Shian-Chaoen_US
dc.contributor.authorMcGrouther, Duncan Angusen_US
dc.date.accessioned2020-06-12T03:41:40Z-
dc.date.available2020-06-12T03:41:40Z-
dc.date.issued2019-
dc.identifier.citationWong, Y.-R., Pang, X., Lim, Z. Y., Du, H., Tay, S.-C., & McGrouther, D. A. (2019). Biomechanical evaluation of peripheral nerves after crush injuries. Heliyon, 5(4), e01557-. doi:10.1016/j.heliyon.2019.e01557en_US
dc.identifier.issn2405-8440en_US
dc.identifier.urihttps://hdl.handle.net/10356/141952-
dc.description.abstractBackground: Crush injury of nerves is a common condition but the biomechanical integrity of the human peripheral nerve after crushing is unknown. This study aims to investigate the impact of crush injury on human digital nerves based on different compressive forces. Materials and methods: Twenty digital nerves were harvested from three fresh-frozen cadaver hands. The original diameters of proximal, middle and distal end of nerve segment were measured. The midst of each digital nerve was compressed by a customized mechanical system, at 1N, 3N and 5N for 30sec. The diameters were measured again within 1 minute after the nerve crush test was performed. The digital nerve was then subjected to biomechanical test to measure its ultimate tensile strength, stiffness, maximum stress and strain. Deformity of digital nerve was computed based on the diameter of middle nerve segment before and after crush test. Results: No significant difference was found in between groups for ultimate tensile strength (p=0.598), stiffness (p=0.593), maximum stress (p=0.7) and strain (p=0.666). The deformity of nerves under the compression of 1N, 3N and 5N was computed at 72.1%, 54.2% and 45.9%. The effect of compression on the deformity of nerves was statistically significant (p<0.001). Conclusions: It was found that the compressive forces have no impact on the biomechanical integrity of peripheral nerves but the deformity of nerves could be severely caused by low compressive force. It is suggested that the management of nerve crush injury shall be taken immediately and focus on neurophysiological function and degeneration of nerves for a crush with low compressive force and short duration.en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.description.sponsorshipMOH (Min. of Health, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofHeliyonen_US
dc.rights© 2019 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.subjectEngineering::Mechanical engineeringen_US
dc.titleBiomechanical evaluation of peripheral nerves after crush injuriesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Mechanical and Aerospace Engineeringen_US
dc.identifier.doi10.1016/j.heliyon.2019.e01557-
dc.description.versionPublished versionen_US
dc.identifier.pmid31183426-
dc.identifier.scopus2-s2.0-85064817345-
dc.identifier.issue4en_US
dc.identifier.volume5en_US
dc.subject.keywordsBiomedical Engineeringen_US
dc.subject.keywordsNeurologyen_US
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item.grantfulltextopen-
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