Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142043
Title: Regenerative rehabilitation : exploring the synergistic effects of rehabilitation and implantation of a bio-functional scaffold in enhancing nerve regeneration
Authors: Lin, Junquan
Anopas, Dollaporn
Milbreta, Ulla
Lin, Po Hen
Chin, Jiah Shin
Zhang, Na
Wee, Seng Kwee
Tow, Adela
Ang, Wei Tech
Chew, Sing Yian
Keywords: Engineering::Bioengineering
Issue Date: 2019
Source: Lin, J., Anopas, D., Milbreta, U., Lin, P. H., Chin, J. S., Zhang, N., . . . Chew, S. Y. (2019). Regenerative rehabilitation : exploring the synergistic effects of rehabilitation and implantation of a bio-functional scaffold in enhancing nerve regeneration. Biomaterials Science, 7(12), 5150-5160. doi:10.1039/C9BM01095E
Journal: Biomaterials Science
Abstract: Clinically, rehabilitation is one of the most common treatment options for traumatic injuries. Despite that, recovery remains suboptimal and recent breakthroughs in regenerative approaches may potentially improve clinical outcomes. To date, there have been numerous studies on the utilization of either rehabilitative or regenerative strategies for traumatic injury treatment. However, studies that document the combined effects of rehabilitation and regenerative tissue engineering options remain scarce. Here, in the context of traumatic nerve injury treatment, we use a rat spinal cord injury (SCI) model as a proof of concept to evaluate the synergistic effects of regenerative tissue engineering and rehabilitation. Specifically, we implanted a pro-regenerative hybrid fiber–hydrogel scaffold and subjected SCI rats to intensive rehabilitation. Of note, the rehabilitation session was augmented by a novel customized training device that imparts normal hindlimb gait movements to rats. Morphologically, more regenerated axons were observed when rats received rehabilitation (∼2.5 times and ∼2 times enhancement after 4 and 12 weeks of recovery, respectively, p < 0.05). Besides that, we also observed a higher percentage of anti-inflammatory cells (36.1 ± 12.9% in rehab rats vs. 3.31 ± 1.48% in non-rehab rats, p < 0.05) and perineuronal net formation in rehab rats at Week 4. Physically, rehab animals were also able to exert higher ankle flexion force (∼0.779 N vs. ∼0.495 N at Week 4 and ∼1.36 N vs. ∼0.647 N at Week 12 for rehab vs. non-rehab rats, p < 0.001) and performed better than non-rehab rats in the open field test. Taken together, we conclude that coupling rehabilitation with regenerative scaffold implantation strategies can further promote functional recovery after traumatic nerve injuries.
URI: https://hdl.handle.net/10356/142043
ISSN: 2047-4830
DOI: 10.1039/C9BM01095E
Rights: © 2019 The Royal Society of Chemistry. All rights reserved. This paper was published in Biomaterials Science and is made available with permission of The Royal Society of Chemistry.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SCBE Journal Articles

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