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Title: In situ organ-specific vascularization in tissue engineering
Authors: Fu, Jiayin
Wang, Dong-An
Keywords: Engineering::Chemical engineering
Issue Date: 2018
Source: Fu, J., & Wang, D.-A. (2018). In situ organ-specific vascularization in tissue engineering. Trends in biotechnology, 36(8), 834-849. doi:10.1016/j.tibtech.2018.02.012
Journal: Trends in biotechnology
Abstract: Other than a few avascular tissues, almost all human tissues are connected to the systemic circulation via blood vessels that promote metabolism and function. Accordingly, engineered vascularization is a vital goal in tissue engineering for regenerative medicine. Endothelial cells (ECs) play a central role in vascularization with two significant specificities: physical interfaces between vascular stroma and blood, and phenotypic organ-specificity. Biomaterial scaffolding technologies that address these unique properties of ECs have been developed to promote the vascularization of various engineered tissues, and these have advanced from mimicking vascular architectures ex situ towards promoting spontaneous angiogenic remodeling in situ. Simultaneously, endothelial progenitor cells (EPCs) and organ-specific ECs are attracting more and more attention with the increasing awareness of the diversity of ECs in different organs.
ISSN: 0167-7799
DOI: 10.1016/j.tibtech.2018.02.012
Rights: © 2018 Elsevier Ltd. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles

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