Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/142058
Title: | Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans | Authors: | Beaudoin-Chabot, Caroline Wang, Lei Smarun, Alexey V. Vidović, Dragoslav Shchepinov, Mikhail S. Thibault, Guillaume |
Keywords: | Science::Biological sciences | Issue Date: | 2019 | Source: | Beaudoin-Chabot, C., Wang, L., Smarun, A. V., Vidović, D., Shchepinov, M. S., & Thibault, G. (2019). Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans. Frontiers in Physiology, 10, 641-. doi:10.3389/fphys.2019.00641 | Journal: | Frontiers in Physiology | Abstract: | Chemically reinforced essential fatty acids (FAs) promise to fight numerous age-related diseases including Alzheimer’s, Friedreich’s ataxia and other neurological conditions. The reinforcement is achieved by substituting the atoms of hydrogen at the bis-allylic methylene of these essential FAs with the isotope deuterium. This substitution leads to a significantly slower oxidation due to the kinetic isotope effect, inhibiting membrane damage. The approach has the advantage of preventing the harmful accumulation of reactive oxygen species (ROS) by inhibiting the propagation of lipid peroxidation while antioxidants potentially neutralize beneficial oxidative species. Here, we developed a model system to mimic the human dietary requirement of omega-3 in Caenorhabditis elegans to study the role of deuterated polyunsaturated fatty acids (D-PUFAs). Deuterated trilinolenin [D-TG(54:9)] was sufficient to prevent the accumulation of lipid peroxides and to reduce the accumulation or ROS. Moreover, D-TG(54:9) significantly extended the lifespan of worms under normal and oxidative stress conditions. These findings demonstrate that D-PUFAs can be used as a food supplement to decelerate the aging process, resulting in extended lifespan. | URI: | https://hdl.handle.net/10356/142058 | ISSN: | 1664-042X | DOI: | 10.3389/fphys.2019.00641 | DOI (Related Dataset): | https://doi.org/10.21979/N9/MGPD5H | Rights: | © 2019 Beaudoin-Chabot, Wang, Smarun, Vidović, Shchepinov and Thibault. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | SBS Journal Articles |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Deuterated Polyunsaturated Fatty Acids Reduce Oxidative Stress and Extend the Lifespan of C. elegans.pdf | 1.88 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
10
25
Updated on Feb 3, 2023
Web of ScienceTM
Citations
10
24
Updated on Feb 3, 2023
Page view(s)
204
Updated on Feb 5, 2023
Download(s) 50
28
Updated on Feb 5, 2023
Google ScholarTM
Check
Altmetric
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.