Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142058
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dc.contributor.authorBeaudoin-Chabot, Carolineen_US
dc.contributor.authorWang, Leien_US
dc.contributor.authorSmarun, Alexey V.en_US
dc.contributor.authorVidović, Dragoslaven_US
dc.contributor.authorShchepinov, Mikhail S.en_US
dc.contributor.authorThibault, Guillaumeen_US
dc.date.accessioned2020-06-15T06:41:39Z-
dc.date.available2020-06-15T06:41:39Z-
dc.date.issued2019-
dc.identifier.citationBeaudoin-Chabot, C., Wang, L., Smarun, A. V., Vidović, D., Shchepinov, M. S., & Thibault, G. (2019). Deuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegans. Frontiers in Physiology, 10, 641-. doi:10.3389/fphys.2019.00641en_US
dc.identifier.issn1664-042Xen_US
dc.identifier.urihttps://hdl.handle.net/10356/142058-
dc.description.abstractChemically reinforced essential fatty acids (FAs) promise to fight numerous age-related diseases including Alzheimer’s, Friedreich’s ataxia and other neurological conditions. The reinforcement is achieved by substituting the atoms of hydrogen at the bis-allylic methylene of these essential FAs with the isotope deuterium. This substitution leads to a significantly slower oxidation due to the kinetic isotope effect, inhibiting membrane damage. The approach has the advantage of preventing the harmful accumulation of reactive oxygen species (ROS) by inhibiting the propagation of lipid peroxidation while antioxidants potentially neutralize beneficial oxidative species. Here, we developed a model system to mimic the human dietary requirement of omega-3 in Caenorhabditis elegans to study the role of deuterated polyunsaturated fatty acids (D-PUFAs). Deuterated trilinolenin [D-TG(54:9)] was sufficient to prevent the accumulation of lipid peroxides and to reduce the accumulation or ROS. Moreover, D-TG(54:9) significantly extended the lifespan of worms under normal and oxidative stress conditions. These findings demonstrate that D-PUFAs can be used as a food supplement to decelerate the aging process, resulting in extended lifespan.en_US
dc.description.sponsorshipMOE (Min. of Education, S’pore)en_US
dc.language.isoenen_US
dc.relation.ispartofFrontiers in Physiologyen_US
dc.relation.urihttps://doi.org/10.21979/N9/MGPD5Hen_US
dc.rights© 2019 Beaudoin-Chabot, Wang, Smarun, Vidović, Shchepinov and Thibault. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleDeuterated polyunsaturated fatty acids reduce oxidative stress and extend the lifespan of C. elegansen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.identifier.doi10.3389/fphys.2019.00641-
dc.description.versionPublished versionen_US
dc.identifier.pmid31191345-
dc.identifier.scopus2-s2.0-85068250503-
dc.identifier.volume10en_US
dc.subject.keywordsPolyunsaturated Fatty Acid (PUFA)en_US
dc.subject.keywordsDeuterated Fatty Aciden_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
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