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dc.contributor.authorYoo, Seong-Keunen_US
dc.contributor.authorKim, Chang-Uken_US
dc.contributor.authorKim, Hie Limen_US
dc.contributor.authorKim, Sungjaeen_US
dc.contributor.authorShin, Jong-Yeonen_US
dc.contributor.authorKim, Namcheolen_US
dc.contributor.authorYang, Joshua Sung Wooen_US
dc.contributor.authorLo, Kwok-Waien_US
dc.contributor.authorCho, Belongen_US
dc.contributor.authorMatsuda, Fumihikoen_US
dc.contributor.authorSchuster, Stephan Christophen_US
dc.contributor.authorKim, Changhoonen_US
dc.contributor.authorKim, Jong-Ilen_US
dc.contributor.authorSeo, Jeong-Sunen_US
dc.identifier.citationYoo, S.-K., Kim, C.-U., Kim, H. L., Kim, S., Shin, J.-Y., Kim, N., . . . Seo, J.-S. (2019). NARD : whole-genome reference panel of 1779 Northeast Asians improves imputation accuracy of rare and low-frequency variants. Genome Medicine, 11(1), 64-. doi:10.1186/s13073-019-0677-zen_US
dc.description.abstractHere, we present the Northeast Asian Reference Database (NARD), including whole-genome sequencing data of 1779 individuals from Korea, Mongolia, Japan, China, and Hong Kong. NARD provides the genetic diversity of Korean (n = 850) and Mongolian (n = 384) ancestries that were not present in the 1000 Genomes Project Phase 3 (1KGP3). We combined and re-phased the genotypes from NARD and 1KGP3 to construct a union set of haplotypes. This approach established a robust imputation reference panel for Northeast Asians, which yields the greatest imputation accuracy of rare and low-frequency variants compared with the existing panels. NARD imputation panel is available at
dc.relation.ispartofGenome Medicineen_US
dc.rights© 2019 The Author(s). This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.en_US
dc.titleNARD : whole-genome reference panel of 1779 Northeast Asians improves imputation accuracy of rare and low-frequency variantsen_US
dc.typeJournal Articleen
dc.contributor.schoolAsian School of the Environmenten_US
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.researchSingapore Centre for Environmental Life Sciences and Engineeringen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsWhole-genome Sequencingen_US
dc.subject.keywordsReference Panelen_US
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