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Title: Conjugative IncX1 plasmid harboring colistin resistance gene mcr-5.1 in Escherichia coli isolated from chicken rice retailed in Singapore
Authors: Guo, Siyao
Tay, Moon Yue Feng
Thu, Aung Kyaw
Seow, Kelyn Lee Ghee
Zhong, Yang
Ng, Lee Ching
Schlundt, Joergen
Keywords: Engineering::Chemical engineering
Issue Date: 2019
Source: Guo, S., Tay, M. Y. F., Thu, A. K., Seow, K. L. G., Zhong, Y., Ng, L. C., & Schlundt, J. (2019). Conjugative IncX1 plasmid harboring Colistin resistance gene mcr-5.1 in Escherichia coli isolated from chicken rice retailed in Singapore. Antimicrobial Agents and Chemotherapy, 63(11), e01043-19-. doi:10.1128/aac.01043-19
Journal: Antimicrobial Agents and Chemotherapy
Abstract: Colistin is regarded as one of the last-resort antimicrobials for treatment of Gram-negative bacterial infections (1). Several cases of plasmid-borne colistin resistance genes mcr-1, mcr-3-like, and mcr-4.2 in clinical Enterobacteriaceae isolates, including Escherichia coli, have been reported in Singapore (2-4). However, the mcr-5 gene has not been reported in clinical isolates in Singapore. Previously, we reported the antimicrobial resistance (AMR) genotype and phenotype of E. coli SGEHI2010ENV103 isolates from ready-to-eat food in Singapore and documented the first isolate carrying mcr-5.1 in Singapore (5). In this study, we further analyzed this isolate. Here, we report the first complete nucleotide sequence of a transferable plasmid harboring mcr-5.1 in E. coli isolated from ready-to-eat chicken rice in Singapore. (Chicken rice is a common dish in Singapore which is composed of cooked chicken and seasoned rice, served with sauce and cucumber garnishes).
ISSN: 0066-4804
DOI: 10.1128/AAC.01043-19
Rights: © 2019 American Society for Microbiology. All rights reserved. This paper was published in Antimicrobial Agents and Chemotherapy and is made available with permission of American Society for Microbiology.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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