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Title: Guanine anchoring : a strategy for specific targeting of a G-quadruplex using short PNA, LNA and DNA molecules
Authors: Tan, Derrick Jing Yang
Das, Poulomi
Winnerdy, Fernaldo Richtia
Lim, Kah Wai
Phan, Anh Tuân
Keywords: Science::Chemistry
Science::Biological sciences
Issue Date: 2020
Source: Tan, D. J. Y., Das, P., Winnerdy, F. R., Lim, K. W., & Phan, A. T. (2020). Guanine anchoring : a strategy for specific targeting of a G-quadruplex using short PNA, LNA and DNA molecules. Chemical Communications, 56(44), 5897-5900. doi:10.1039/d0cc01778g
Project: NRF-NRFI2017-09
Journal: Chemical Communications
Abstract: Two separate structural elements of a G-quadruplex (G4), a vacant site and a flanking single-strand, provide an opportunity for specific targeting of a particular G4 structure via dual recognition. Here, we show that a short peptide nucleic acid (PNA) can specifically recognize and bind to a G4 at sub-micromolar affinity based on both G-tetrad vacant site filling and complementary duplex formation. This sequence-guided guanine-anchoring strategy can be further developed for specific targeting of G4 structures using short DNA, LNA and PNA strands.
ISSN: 1359-7345
DOI: 10.1039/d0cc01778g
Rights: © 2020 The Royal Society of Chemistry. All rights reserved. This paper was published in Chemical Communications and is made available with permission of The Royal Society of Chemistry.
Fulltext Permission: embargo_20210504
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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