Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142127
Title: Gold nanoparticle should understand protein corona for being a clinical nanomaterial
Authors: Charbgoo, Fahimeh
Nejabat, Mojgan
Abnous, Khalil
Soltani, Fatemeh
Seyed Mohammad Taghdisi
Alibolandi, Mona
Shier, W. Thomas
Steele, Terry W. J.
Mohammad Ramezani
Keywords: Engineering::Materials
Issue Date: 2018
Source: Charbgoo, F., Nejabat, M., Abnous, K., Soltani, F., Seyed Mohammad Taghdisi., Alibolandi, M., . . . Mohammad Ramezani. (2018). Gold nanoparticle should understand protein corona for being a clinical nanomaterial. Journal of Controlled Release, 272, 39-53. doi:10.1016/j.jconrel.2018.01.002
Journal: Journal of Controlled Release
Abstract: Gold nanoparticles (AuNPs) have attracted great attention in biomedical fields due to their unique properties. However, there are few reports on clinical trial of these nanoparticles. In vivo, AuNPs face complex biological fluids containing abundant proteins, which challenge the prediction of their fate that is known as "bio-identity". These proteins attach onto the AuNPs surface forming protein corona that makes the first step of nano-bio interface and dictates the subsequent AuNPs fate. Protein corona formation even stealth active targeting effect of AuNPs. Manipulating the protein corona identity based on the researcher goal is the way to employ corona to achieve maximum effect in therapy or other applications. In this review, we provide details on the biological identity of AuNPs under various environmental- and/or physiological conditions. We also highlight how the particular corona can direct the biodistribution of AuNPs. We further discuss the strategies available for controlling or reducing corona formation on AuNPs surface and achieving desired effects using AuNPs in vivo by engineering protein corona on their surface.
URI: https://hdl.handle.net/10356/142127
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2018.01.002
Rights: © 2018 Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:MSE Journal Articles

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