Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142173
Title: NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes
Authors: Winnerdy, Fernaldo Richtia
Bakalar, Blaž
Maity, Arijit
Vandana, J. Jeya
Mechulam, Yves
Schmitt, Emmanuelle
Phan, Anh Tuân
Keywords: Science::Physics
Issue Date: 2019
Source: Winnerdy, F. R., Bakalar, B., Maity, A., Vandana, J. J., Mechulam, Y., Schmitt, E., & Phan, A. T. (2019). NMR solution and X-ray crystal structures of a DNA molecule containing both right- and left-handed parallel-stranded G-quadruplexes. Nucleic Acids Research, 47(15), 8272-8281. doi:10.1093/nar/gkz349
Journal: Nucleic Acids Research
Abstract: Analogous to the B- and Z-DNA structures in double-helix DNA, there exist both right- and left-handed quadruple-helix (G-quadruplex) DNA. Numerous conformations of right-handed and a few left-handed G-quadruplexes were previously observed, yet they were always identified separately. Here, we present the NMR solution and X-ray crystal structures of a right- and left-handed hybrid G-quadruplex. The structure reveals a stacking interaction between two G-quadruplex blocks with different helical orientations and displays features of both right- and left-handed G-quadruplexes. An analysis of loop mutations suggests that single-nucleotide loops are preferred or even required for the left-handed G-quadruplex formation. The discovery of a right- and left-handed hybrid G-quadruplex further expands the polymorphism of G-quadruplexes and is potentially useful in designing a left-to-right junction in G-quadruplex engineering.
URI: https://hdl.handle.net/10356/142173
ISSN: 0305-1048
DOI: 10.1093/nar/gkz349
Rights: © 2019 The Author(s) (Published by Oxford University Press on behalf of Nucleic Acids Research). This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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