Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142180
Title: Switch and trace : recombinase genetics in zebrafish
Authors: Carney, Tom J.
Mosimann, Christian
Keywords: Science::Medicine
Issue Date: 2018
Source: Carney, Tom J., & Mosimann, C. (2018). Switch and trace : recombinase genetics in zebrafish. Trends in genetics, 34(5), 362-378. doi:10.1016/j.tig.2018.01.004
Journal: Trends in genetics
Abstract: Transgenic approaches are instrumental for labeling and manipulating cells and cellular machineries in vivo. Transgenes have traditionally been static entities that remained unaltered following genome integration, limiting their versatility. The development of DNA recombinase-based methods to modify, excise, or rearrange transgene cassettes has introduced versatile control of transgene activity and function. In particular, recombinase-controlled transgenes enable regulation of exogenous gene expression, conditional mutagenesis, and genetic lineage tracing. In zebrafish, transgenesis-based recombinase genetics using Cre/lox, Flp/FRT, and ΦC31 are increasingly applied to study development and homeostasis, and to generate disease models. Intersected with the versatile imaging capacity of the zebrafish model and recent breakthroughs in genome editing, we review and discuss past, current, and potential future approaches and resources for recombinase-based techniques in zebrafish.
URI: https://hdl.handle.net/10356/142180
ISSN: 0168-9525
DOI: 10.1016/j.tig.2018.01.004
Rights: © 2018 Elsevier Ltd. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:LKCMedicine Journal Articles

SCOPUSTM   
Citations 10

33
Updated on Jan 30, 2023

Web of ScienceTM
Citations 10

33
Updated on Jan 31, 2023

Page view(s)

166
Updated on Feb 5, 2023

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.