Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142188
Title: Non-invasive optical focusing inside strongly scattering media with linear fluorescence
Authors: Li, Dayan
Sahoo, Sujit Kumar
Lam, Huy Quoc
Wang, Dong
Dang, Cuong
Keywords: Engineering::Electrical and electronic engineering
Issue Date: 2020
Source: Li, D., Sahoo, S. K., Lam, H. Q., Wang, D., & Dang, C. (2020). Non-invasive optical focusing inside strongly scattering media with linear fluorescence. Applied Physics Letters, 116(24), 241104-. doi:10.1063/5.0004071
Journal: Applied Physics Letters
Abstract: Non-invasive optical focusing inside scattering media is still a big challenge because inhomogeneous media scatter incoming photons for focusing and outgoing photons for observation. Various approaches, utilizing non-linear fluorescence or ultrasound, have been reported to address this difficulty. However, implementation of these methods is complicated and highly expensive, as ultrafast laser systems or photoacoustic equipment must be employed. Here, we demonstrate a wavefront shaping technique to achieve non-invasive focusing inside scattering media using only a linear fluorescent signal. The contrast and mean of incoherent speckles, produced by the linear fluorescence, are utilized as feedback signals to optimize the input wavefront. While increasing speckle contrast makes the focus tighter and increasing the speckle mean enhances the intensity, fine-tuning the contribution of these two factors in our two-step optimization is essential. An optimal wavefront is found to achieve simultaneously both a micrometer focal spot size (down to 20 lm diameter) and high intensity (more than a 100-fold enhancement) inside the scattering media. Our method promises a route in life science toward focusing, imaging, or manipulating deep into biological tissues with linear fluorescent agents.
URI: https://hdl.handle.net/10356/142188
ISSN: 0003-6951
DOI: 10.1063/5.0004071
Rights: © 2020 The Author(s). All rights reserved. This paper was published by AIP Publishing in Applied Physics Letters and is made available with permission of The Author(s).
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles

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