Identification of new drug targets using microarrays and proteomic.

Abstract

1. Gene profiling in Plusmodiurn falciparum and the rodent malaria parasites in response to small inhibitor treatment 2. Determine changes in the proteorne in response to small inhibitors 3. Determination of biochemical and functional pathways 4. Functional characterization of the identified drug targets by intracellular localizations and targeted gene disruptions 5. Elucidations of DNA regulatory elements involved in transcriptional regulation of plasmodium genes during invasion