Please use this identifier to cite or link to this item:
|Title:||MMP14 in sarcoma : a regulator of tumor microenvironment communication in connective tissues||Authors:||Gonzalez-Molina, Jordi
Carlson, Joseph W.
Ojala, Päivi M.
|Keywords:||Science::Biological sciences||Issue Date:||2019||Source:||Gonzalez-Molina, J., Gramolelli, S., Liao, Z., Carlson, J. W., Ojala, P. M., & Lehti, K. (2019). MMP14 in sarcoma : a regulator of tumor microenvironment communication in connective tissues. Cells, 8(9), 991-. doi:10.3390/cells8090991||Journal:||Cells||Abstract:||Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell–cell and cell–extracellular matrix (ECM) communication. This regulation mediates processes such as ECM degradation and remodeling, cell invasion, and cancer metastasis. Thus, a comprehensive understanding of the biology of MMP14 in sarcomas will shed light on the mechanisms controlling the key processes in these diseases. Here, we provide an overview of the function and regulation of MMP14 and we discuss their relationship with clinical and pre-clinical MMP14 data in both adult and childhood sarcomas.||URI:||https://hdl.handle.net/10356/142264||ISSN:||2073-4409||DOI:||10.3390/cells8090991||Rights:||© 2019 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SBS Journal Articles|
Files in This Item:
|MMP14 in Sarcoma A Regulator of Tumor Microenvironment Communication in Connective Tissues.pdf||2.13 MB||Adobe PDF||View/Open|
Updated on Feb 1, 2023
Web of ScienceTM
Updated on Jan 30, 2023
Updated on Feb 5, 2023
Updated on Feb 5, 2023
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.