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Title: MMP14 in sarcoma : a regulator of tumor microenvironment communication in connective tissues
Authors: Gonzalez-Molina, Jordi
Gramolelli, Silvia
Liao, Zehuan
Carlson, Joseph W.
Ojala, Päivi M.
Lehti, Kaisa
Keywords: Science::Biological sciences
Issue Date: 2019
Source: Gonzalez-Molina, J., Gramolelli, S., Liao, Z., Carlson, J. W., Ojala, P. M., & Lehti, K. (2019). MMP14 in sarcoma : a regulator of tumor microenvironment communication in connective tissues. Cells, 8(9), 991-. doi:10.3390/cells8090991
Journal: Cells
Abstract: Sarcomas are deadly malignant tumors of mesenchymal origin occurring at all ages. The expression and function of the membrane-type matrix metalloproteinase MMP14 is closely related to the mesenchymal cell phenotype, and it is highly expressed in most sarcomas. MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell–cell and cell–extracellular matrix (ECM) communication. This regulation mediates processes such as ECM degradation and remodeling, cell invasion, and cancer metastasis. Thus, a comprehensive understanding of the biology of MMP14 in sarcomas will shed light on the mechanisms controlling the key processes in these diseases. Here, we provide an overview of the function and regulation of MMP14 and we discuss their relationship with clinical and pre-clinical MMP14 data in both adult and childhood sarcomas.
ISSN: 2073-4409
DOI: 10.3390/cells8090991
Rights: © 2019 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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