Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142282
Title: Mechanistic insights into the evolution of DUF26-containing proteins in land plants
Authors: Vaattovaara, Aleksia
Brandt, Benjamin
Rajaraman, Sitaram
Safronov, Omid
Veidenberg, Andres
Luklová, Markéta
Kangasjärvi, Jaakko
Löytynoja, Ari
Hothorn, Michael
Salojärvi, Jarkko
Wrzaczek, Michael
Keywords: Science::Biological sciences
Issue Date: 2019
Source: Vaattovaara, A., Brandt, B., Rajaraman, S., Safronov, O., Veidenberg, A., Luklová, M., . . . Wrzaczek, M. (2019). Mechanistic insights into the evolution of DUF26-containing proteins in land plants. Communications Biology, 2(1), 56-. doi:10.1038/s42003-019-0306-9
Journal: Communications Biology
Abstract: Large protein families are a prominent feature of plant genomes and their size variation is a key element for adaptation. However, gene and genome duplications pose difficulties for functional characterization and translational research. Here we infer the evolutionary history of the DOMAIN OF UNKNOWN FUNCTION (DUF) 26-containing proteins. The DUF26 emerged in secreted proteins. Domain duplications and rearrangements led to the appearance of CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASES (CRKs) and PLASMODESMATA-LOCALIZED PROTEINS (PDLPs). The DUF26 is land plant-specific but structural analyses of PDLP ectodomains revealed strong similarity to fungal lectins and thus may constitute a group of plant carbohydrate-binding proteins. CRKs expanded through tandem duplications and preferential retention of duplicates following whole genome duplications, whereas PDLPs evolved according to the dosage balance hypothesis. We propose that new gene families mainly expand through small-scale duplications, while fractionation and genetic drift after whole genome multiplications drive families towards dosage balance.
URI: https://hdl.handle.net/10356/142282
ISSN: 2399-3642
DOI: 10.1038/s42003-019-0306-9
Rights: © The Author(s) (Published by Springer Nature). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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