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dc.contributor.authorChen, Swaine Linen_US
dc.contributor.authorDing, Yingen_US
dc.contributor.authorApisarnthanarak, Anuchaen_US
dc.contributor.authorKalimuddin, Shirinen_US
dc.contributor.authorArchuleta, Sophiaen_US
dc.contributor.authorSharifah Faridah Syed Omaren_US
dc.contributor.authorDe, Partha Pratimen_US
dc.contributor.authorKoh, Tse Hsienen_US
dc.contributor.authorChew, Kean Leeen_US
dc.contributor.authorNadia Atiyaen_US
dc.contributor.authorSuwantarat, Nuntraen_US
dc.contributor.authorVelayuthan, Rukumani Devien_US
dc.contributor.authorWong, Joshua Guo Xianen_US
dc.contributor.authorLye, David C.en_US
dc.identifier.citationChen, S. L., Ding, Y., Apisarnthanarak, A., Kalimuddin, S., Archuleta, S., Sharifah Faridah Syed Omar, . . . Lye, D. C. (2019). The higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone. Scientific Reports, 9(1), 13245-. doi:10.1038/s41598-019-49467-5en_US
dc.description.abstractThe ST131 multilocus sequence type (MLST) of Escherichia coli is a globally successful pathogen whose dissemination is increasing rates of antibiotic resistance. Numerous global surveys have demonstrated the pervasiveness of this clone; in some regions ST131 accounts for up to 30% of all E. coli isolates. However, many regions are underrepresented in these published surveys, including Africa, South America, and Asia. We collected consecutive bloodstream E. coli isolates from three countries in Southeast Asia; ST131 was the most common MLST type. As in other studies, the C2/H30Rx clade accounted for the majority of ST131 strains. Clinical risk factors were similar to other reported studies. However, we found that nearly all of the C2 strains in this study were closely related, forming what we denote the SEA-C2 clone. The SEA-C2 clone is enriched for strains from Asia, particularly Southeast Asia and Singapore. The SEA-C2 clone accounts for all of the excess resistance and virulence of ST131 relative to non-ST131 E. coli. The SEA-C2 strains appear to be locally circulating and dominant in Southeast Asia, despite the intuition that high international connectivity and travel would enable frequent opportunities for other strains to establish themselves.en_US
dc.description.sponsorshipASTAR (Agency for Sci., Tech. and Research, S’pore)en_US
dc.description.sponsorshipNMRC (Natl Medical Research Council, S’pore)en_US
dc.relation.ispartofScientific Reportsen_US
dc.rights© 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
dc.titleThe higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subcloneen_US
dc.typeJournal Articleen
dc.contributor.schoolLee Kong Chian School of Medicine (LKCMedicine)en_US
dc.description.versionPublished versionen_US
dc.subject.keywordsEscherichia Colien_US
dc.subject.keywordsST131 Multilocus Sequence Type (MLST)en_US
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