Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142340
Title: The higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone
Authors: Chen, Swaine Lin
Ding, Ying
Apisarnthanarak, Anucha
Kalimuddin, Shirin
Archuleta, Sophia
Sharifah Faridah Syed Omar
De, Partha Pratim
Koh, Tse Hsien
Chew, Kean Lee
Nadia Atiya
Suwantarat, Nuntra
Velayuthan, Rukumani Devi
Wong, Joshua Guo Xian
Lye, David C.
Keywords: Science::Medicine
Issue Date: 2019
Source: Chen, S. L., Ding, Y., Apisarnthanarak, A., Kalimuddin, S., Archuleta, S., Sharifah Faridah Syed Omar, . . . Lye, D. C. (2019). The higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone. Scientific Reports, 9(1), 13245-. doi:10.1038/s41598-019-49467-5
Journal: Scientific Reports
Abstract: The ST131 multilocus sequence type (MLST) of Escherichia coli is a globally successful pathogen whose dissemination is increasing rates of antibiotic resistance. Numerous global surveys have demonstrated the pervasiveness of this clone; in some regions ST131 accounts for up to 30% of all E. coli isolates. However, many regions are underrepresented in these published surveys, including Africa, South America, and Asia. We collected consecutive bloodstream E. coli isolates from three countries in Southeast Asia; ST131 was the most common MLST type. As in other studies, the C2/H30Rx clade accounted for the majority of ST131 strains. Clinical risk factors were similar to other reported studies. However, we found that nearly all of the C2 strains in this study were closely related, forming what we denote the SEA-C2 clone. The SEA-C2 clone is enriched for strains from Asia, particularly Southeast Asia and Singapore. The SEA-C2 clone accounts for all of the excess resistance and virulence of ST131 relative to non-ST131 E. coli. The SEA-C2 strains appear to be locally circulating and dominant in Southeast Asia, despite the intuition that high international connectivity and travel would enable frequent opportunities for other strains to establish themselves.
URI: https://hdl.handle.net/10356/142340
ISSN: 2045-2322
DOI: 10.1038/s41598-019-49467-5
Rights: © 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

SCOPUSTM   
Citations 20

13
Updated on Oct 4, 2022

Web of ScienceTM
Citations 20

15
Updated on Oct 4, 2022

Page view(s)

136
Updated on Oct 5, 2022

Download(s) 50

31
Updated on Oct 5, 2022

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.