Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142348
Title: Factors influencing quality of life in children with atopic dermatitis and their caregivers : a cross-sectional study
Authors: Xu, Xiaomeng
van Galen, Louise Sandra
Koh, Mark Jean Aan
Bajpai, Ram
Thng, Steven
Yew, Yik Weng
Ho, Valerie Pui Yoong
Alagappan, Uma
Järbrink, Krister Sven Ake
Car, Josip
Keywords: Science::Medicine
Issue Date: 2019
Source: Xu, X., van Galen, L. S., Koh, M. J. A., Bajpai, R., Thng, S., Yew, Y. W., . . . Car, J. (2019). Factors influencing quality of life in children with atopic dermatitis and their caregivers : a cross-sectional study. Scientific Reports, 9(1), 15990-. doi:10.1038/s41598-019-51129-5
Journal: Scientific Reports
Abstract: Better understanding of atopic dermatitis' effect on quality of life could enhance current management and therapeutic strategies. Studies investigating factors related to the health-related quality of life (HRQOL) of children with atopic dermatitis and their caregivers are limited. This cross-sectional study included 559 children (<16 years) with atopic dermatitis and their caregivers. Disease severity was associated with infants' HRQOL (moderate: IRR: 1.42, 95% CI 1.20-1.67; severe: IRR: 1.72, 95% CI 1.32-2.24). Age and disease severity were associated with children's HRQOL (age: IRR: 0.99, 95% CI 0.98-1.00; moderate: IRR: 1.08, 95% CI 1.02-1.14). Quality of life subdomains itching/scratching, emotional distress and sleep disturbance were most reported and increased with higher disease severity. Both caregivers' mental and physical health were negatively affected by children's HRQOL (physical: IRR: 0.99, 95% CI 0.99-1.00; mental: IRR: 0.98, 95% CI 0.97-0.99). Sociodemographic characteristics (gender, ethnicity, educational attainment of carers, number of children) did not demonstrate significance in children's HRQOL model. In conclusion, current atopic dermatitis diagnostics and treatment have to be extended to the factors influencing both children' as their caregivers' quality of life and adapting management accordingly. Itching/scratching, emotional distress and sleep disturbance deserve attention. Sociodemographic characteristics in children's HRQOL models also merit attention in further research.
URI: https://hdl.handle.net/10356/142348
ISSN: 2045-2322
DOI: 10.1038/s41598-019-51129-5
Rights: © 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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