Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142368
Title: Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds
Authors: Guo, Zhong
He, Jing-Xi
Mahadevegowda, Surendra Hittanahalli
Kho, Shu Hui
Chan-Park, Mary B.
Liu, Xue-Wei
Keywords: Science::Chemistry
Issue Date: 2020
Source: Guo, Z., He, J.-X., Mahadevegowda, S. H., Kho, S. H., Chan‐Park, M. B., & Liu, X.-W. (2020). Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds. Advanced Healthcare Materials, 9(10), 2000265-. doi:10.1002/adhm.202000265
Journal: Advanced Healthcare Materials
Abstract: Bacterial infection is becoming increasingly lethal with the emergence of antimicrobial resistance, and wounds plagued by such infection are notoriously difficult to heal. Here, the first use of galactose‐black phosphorus nanosheets, (Gal‐BP NSs) as a delivery platform for synergistic antibiotic (kanamycin, Kana) and photothermal treatments against the Gram‐negative microbial strain, Pseudomonas aeruginosa PAO1 (PAO1) is reported. Gal‐BP NSs@Kana can actively target PAO1 and release kanamycin into the bacterial cytoplasm upon near‐infrared laser irradiation. This strategy kills most of the PAO1 through a simultaneous burst of intracellular kanamycin release and photothermal treatment. Comparable antibacterial activities of Gal‐BP NSs@Kana are observed within in vivo mouse models at their wound sites. In addition, this platform accelerates wound healing from PAO1 infection via promotion of neoangiogenesis and collagen production at the wound sites. This work demonstrates the material properties of Gal‐BP NS in fighting bacterial infections and in the treatment of wound healing.
URI: https://hdl.handle.net/10356/142368
ISSN: 2192-2640
DOI: 10.1002/adhm.202000265
Rights: This is the accepted version of the following article: Guo, Z., He, J.-X., Mahadevegowda, S. H., Kho, S. H., Chan‐Park, M. B., & Liu, X.-W. (2020). Multifunctional glyco‐nanosheets to eradicate drug‐resistant bacteria on wounds. Advanced Healthcare Materials, 9(10), 2000265-. doi:10.1002/adhm.202000265, which has been published in final form at https://doi.org/10.1002/adhm.202000265. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles

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