Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142452
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dc.contributor.authorCao, Zhonglinen_US
dc.contributor.authorXiao, Huiyuen_US
dc.contributor.authorLi, Lien_US
dc.contributor.authorLiu, Maixianen_US
dc.contributor.authorLin, Guimiaoen_US
dc.contributor.authorZhai, Pengen_US
dc.contributor.authorYong, Ken-Tyeen_US
dc.contributor.authorWang, Xiaomeien_US
dc.contributor.authorXu, Gaixiaen_US
dc.date.accessioned2020-06-22T06:40:53Z-
dc.date.available2020-06-22T06:40:53Z-
dc.date.issued2019-
dc.identifier.citationCao, Z., Xiao, H., Li, L., Liu, M., Lin, G., Zhai, P., . . . Xu, G. (2019). The codelivery of siRNA and QDs by pH-responsive micelle for hepatoma cancer cells. Frontiers in Pharmacology, 10, 1194-. doi:10.3389/fphar.2019.01194en_US
dc.identifier.issn1663-9812en_US
dc.identifier.urihttps://hdl.handle.net/10356/142452-
dc.description.abstractRecently, RNA interfering (RNAi) has become a promising approach for cancer therapy. However, the application of RNAi for clinics is still hindered due to the lack of safe and efficient carriers. In this study, a pH-responsive micelle based on polycaprolactone-block-poly 2-(dimethylamino)ethyl methacrylate (PCL-PDEM) cationic copolymer was developed to carry short interfering RNA (siRNA) for silencing interleukin 8 (IL-8) gene in hepatoma cancer cells. The transfection efficiency of the PCL-PDEM-siRNA/quantum dots (QDs) nanoplex has reached about 70%, and the expression level of IL-8 decreased about 63%. Furthermore, the codelivery of QDs and siRNA has been realized, which is beneficial to visualize the process of siRNA delivery. No considerable cytotoxicity from the nanoparticles has been observed, indicating that our responsive cationic micelle is potential in clinical trial for hepatoma cancer therapy.en_US
dc.language.isoenen_US
dc.relation.ispartofFrontiers in Pharmacologyen_US
dc.rights© 2019 Cao, Xiao, Li, Liu, Lin, Zhai, Yong, Wang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectEngineering::Electrical and electronic engineeringen_US
dc.titleThe codelivery of siRNA and QDs by pH-responsive micelle for hepatoma cancer cellsen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Electrical and Electronic Engineeringen_US
dc.identifier.doi10.3389/fphar.2019.01194-
dc.description.versionPublished versionen_US
dc.identifier.pmid31680969-
dc.identifier.scopus2-s2.0-85074214793-
dc.identifier.volume10en_US
dc.subject.keywordssiRNAen_US
dc.subject.keywordsQDsen_US
item.grantfulltextopen-
item.fulltextWith Fulltext-
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