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Title: The codelivery of siRNA and QDs by pH-responsive micelle for hepatoma cancer cells
Authors: Cao, Zhonglin
Xiao, Huiyu
Li, Li
Liu, Maixian
Lin, Guimiao
Zhai, Peng
Yong, Ken-Tye
Wang, Xiaomei
Xu, Gaixia
Keywords: Engineering::Electrical and electronic engineering
Issue Date: 2019
Source: Cao, Z., Xiao, H., Li, L., Liu, M., Lin, G., Zhai, P., . . . Xu, G. (2019). The codelivery of siRNA and QDs by pH-responsive micelle for hepatoma cancer cells. Frontiers in Pharmacology, 10, 1194-. doi:10.3389/fphar.2019.01194
Journal: Frontiers in Pharmacology
Abstract: Recently, RNA interfering (RNAi) has become a promising approach for cancer therapy. However, the application of RNAi for clinics is still hindered due to the lack of safe and efficient carriers. In this study, a pH-responsive micelle based on polycaprolactone-block-poly 2-(dimethylamino)ethyl methacrylate (PCL-PDEM) cationic copolymer was developed to carry short interfering RNA (siRNA) for silencing interleukin 8 (IL-8) gene in hepatoma cancer cells. The transfection efficiency of the PCL-PDEM-siRNA/quantum dots (QDs) nanoplex has reached about 70%, and the expression level of IL-8 decreased about 63%. Furthermore, the codelivery of QDs and siRNA has been realized, which is beneficial to visualize the process of siRNA delivery. No considerable cytotoxicity from the nanoparticles has been observed, indicating that our responsive cationic micelle is potential in clinical trial for hepatoma cancer therapy.
ISSN: 1663-9812
DOI: 10.3389/fphar.2019.01194
Rights: © 2019 Cao, Xiao, Li, Liu, Lin, Zhai, Yong, Wang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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