Please use this identifier to cite or link to this item:
Title: CG-NAP/kinase interactions fine-tune T cell functions
Authors: Verma, Navin Kumar
Chalasani, Madhavi Latha Somaraju
Scott, John D.
Kelleher, Dermot
Keywords: Science::Medicine
Issue Date: 2019
Source: Verma, N. K., Chalasani, M. L. S., Scott, J. D., & Kelleher, D. (2019). CG-NAP/kinase interactions fine-tune T cell functions. Frontiers in Immunology, 10, 2642-. doi:10.3389/fimmu.2019.02642
Journal: Frontiers in Immunology
Abstract: CG-NAP, also known as AKAP450, is an anchoring/adaptor protein that streamlines signal transduction in various cell types by localizing signaling proteins and enzymes with their substrates. Great efforts are being devoted to elucidating functional roles of this protein and associated macromolecular signaling complex. Increasing understanding of pathways involved in regulating T lymphocytes suggests that CG-NAP can facilitate dynamic interactions between kinases and their substrates and thus fine-tune T cell motility and effector functions. As a result, new binding partners of CG-NAP are continually being uncovered. Here, we review recent advances in CG-NAP research, focusing on its interactions with kinases in T cells with an emphasis on the possible role of this anchoring protein as a target for therapeutic intervention in immune-mediated diseases.
ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.02642
Rights: © 2019 Verma, Chalasani, Scott and Kelleher. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

Files in This Item:
File Description SizeFormat 
CG-NAPKinase Interactions Fine-Tune T Cell Functions.pdf1.49 MBAdobe PDFThumbnail

Citations 50

Updated on Mar 10, 2021

Citations 20

Updated on Mar 8, 2021

Page view(s)

Updated on May 26, 2022


Updated on May 26, 2022

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.