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dc.contributor.authorNatali, Federicaen_US
dc.contributor.authorRancati, Giuliaen_US
dc.identifier.citationNatali, F., & Rancati, G. (2019). The mutator phenotype : adapting microbial evolution to cancer biology. Frontiers in Genetics, 10, 713-. doi:10.3389/fgene.2019.00713en_US
dc.description.abstractThe mutator phenotype hypothesis was postulated almost 40 years ago to reconcile the observation that while cancer cells display widespread mutational burden, acquisition of mutations in non-transformed cells is a rare event. Moreover, it also suggested that cancer evolution could be fostered by increased genome instability. Given the evolutionary conservation throughout the tree of life and the genetic tractability of model organisms, yeast and bacterial species pioneered studies to dissect the functions of genes required for genome maintenance (caretaker genes) or for cell growth control (gatekeeper genes). In this review, we first provide an overview of what we learned from model organisms about the roles of these genes and the genome instability that arises as a consequence of their dysregulation. We then discuss our current understanding of how mutator phenotypes shape the evolution of bacteria and yeast species. We end by bringing clinical evidence that lessons learned from single-cell organisms can be applied to tumor evolution.en_US
dc.description.sponsorshipNRF (Natl Research Foundation, S’pore)en_US
dc.relation.ispartofFrontiers in Geneticsen_US
dc.rights© 2019 Natali and Rancati. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectScience::Biological sciencesen_US
dc.titleThe mutator phenotype : adapting microbial evolution to cancer biologyen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Biological Sciencesen_US
dc.contributor.organizationInstitute of Medical Biology, A*STARen_US
dc.description.versionPublished versionen_US
dc.subject.keywordsMutator Phenotypeen_US
dc.subject.keywordsCell-to-cell Heterogeneityen_US
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