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Title: The mutator phenotype : adapting microbial evolution to cancer biology
Authors: Natali, Federica
Rancati, Giulia
Keywords: Science::Biological sciences
Issue Date: 2019
Source: Natali, F., & Rancati, G. (2019). The mutator phenotype : adapting microbial evolution to cancer biology. Frontiers in Genetics, 10, 713-. doi:10.3389/fgene.2019.00713
Journal: Frontiers in Genetics
Abstract: The mutator phenotype hypothesis was postulated almost 40 years ago to reconcile the observation that while cancer cells display widespread mutational burden, acquisition of mutations in non-transformed cells is a rare event. Moreover, it also suggested that cancer evolution could be fostered by increased genome instability. Given the evolutionary conservation throughout the tree of life and the genetic tractability of model organisms, yeast and bacterial species pioneered studies to dissect the functions of genes required for genome maintenance (caretaker genes) or for cell growth control (gatekeeper genes). In this review, we first provide an overview of what we learned from model organisms about the roles of these genes and the genome instability that arises as a consequence of their dysregulation. We then discuss our current understanding of how mutator phenotypes shape the evolution of bacteria and yeast species. We end by bringing clinical evidence that lessons learned from single-cell organisms can be applied to tumor evolution.
ISSN: 1664-3224
DOI: 10.3389/fgene.2019.00713
Schools: School of Biological Sciences 
Organisations: Institute of Medical Biology, A*STAR
Rights: © 2019 Natali and Rancati. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SBS Journal Articles

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