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Title: In vitro and In vivo photothermal cancer therapeutic effects of gold nanorods modified with mushroom β-glucan
Authors: Li, Xiaojie
Zhou, Jiajing
Dong, Xiaonan
Cheng, Wai-Yin
Duan, Hongwei
Cheung, Peter C. K.
Keywords: Engineering::Chemical engineering
Issue Date: 2018
Source: Li, X., Zhou, J., Dong, X., Cheng, W.-Y., Duan, H., & Cheung, P. C. K. (2018). In vitro and In vivo photothermal cancer therapeutic effects of gold nanorods modified with mushroom β-glucan. Journal of agricultural and food chemistry, 66(16), 4091–4098. doi:10.1021/acs.jafc.8b00292
Journal: Journal of agricultural and food chemistry
Abstract: The photothermal cancer therapeutic effect of the AuNR-Glu nanohybrids produced by coating native gold nanorods (AuNRs) with a natural mushroom biopolymer from the Pleurotus tuber-regium sclerotia (Glu) were studied in the second near-infrared window (NIR-II). The AuNR-Glu exhibited low cytotoxicity and high biocompatibility due to the surface modification of Glu when compared with the native AuNRs. AuNR-Glu nanohybrids had a high photothermal transduction efficiency (η) of 43.12%, causing effective in vitro cell ablation in both HT-29 (94.2 ± 0.8% cell death) and SW480 (94.8 ± 1.1% cell death) colon cancer cells under 1064 nm NIR-II laser irradiation at 1.0 W/cm2. Intravenous injection of AuNR-Glu nanohybrids followed by irradiation from a NIR-II laser at a safe dose (1.0 W/cm2 for 5 min) in nude mice implanted with HT-29 tumors was effective in significantly reducing the tumor growth, with no obvious harmful side effects, as evidenced by histological analysis of major organs. The present results have shown that AuNRs modified by natural biopolymers from mushroom β-glucans are novel nanomaterials with low cytotoxicity and effective photothermal anticancer agents with potential biomedical applications.
ISSN: 0021-8561
DOI: 10.1021/acs.jafc.8b00292
Rights: © 2018 American Chemical Society. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SCBE Journal Articles


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