Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142698
Title: Investigation on chemical protease, nuclease and catecholase activity of two copper complexes with flexidentate Schiff base ligands
Authors: Das, Mriganka
Kundu, Bidyut Kumar
Tiwari, Ritudhwaj
Mandal, Poulami
Nayak, Debasis
Ganguly, Rakesh
Mukhopadhyay, Suman
Keywords: Science::Chemistry
Issue Date: 2018
Source: Das, M., Kundu, B. K., Tiwari, R., Mandal, P., Nayak, D., Ganguly, R., & Mukhopadhyay, S. (2018). Investigation on chemical protease, nuclease and catecholase activity of two copper complexes with flexidentate Schiff base ligands. Inorganica Chimica Acta, 469, 111-122. doi:10.1016/j.ica.2017.09.013
Journal: Inorganica Chimica Acta
Abstract: Two new Cu(II) complexes [Cu(HL)(MeOH)(Py)](ClO4)2 (1), [Cu(HL)(DMF])(NO3)2 (2) have been synthesized from Schiff base ligand [HL = 2-(phenyl((2-(piperazin-1-yl)ethyl)imino)methyl)phenol ] with flexible piperazinyl moiety. Structural analysis reveals that 1 and 2 are monomeric Cu(II) complex consisting of penta and tetra coordinated Cu(II) centers, respectively. Screening tests were conducted to quantify the binding ability of complexes (1 and 2) towards BSA and DNA as well as the protease and nuclease activity of these complexes using gel electrophoresis technique. Furthermore enzyme kinetic studies were also performed for those two complexes towards effectiveness in mimicking catecholase like activities. Overall all the experimental results reveal the potential activity of these copper complexes towards protease, nuclease and catecholase activity. Apart from these, MTT assay was also utilized to scrutinize the anti-proliferative activity which was further investigated using dual staining confocal microscopic images.
URI: https://hdl.handle.net/10356/142698
ISSN: 0020-1693
DOI: 10.1016/j.ica.2017.09.013
Rights: © 2017 Elsevier B.V. All rights reserved.
Fulltext Permission: none
Fulltext Availability: No Fulltext
Appears in Collections:SPMS Journal Articles

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