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https://hdl.handle.net/10356/142742| Title: | The GenomeAsia 100K Project enables genetic discoveries across Asia | Authors: | Wall, Jeffrey D. Stawiski, Eric W. Ratan, Aakrosh Kim, Hie Lim Kim, Changhoon Gupta, Ravi Suryamohan, Kushal Gusareva, Elena S. Purbojati, Rikky Wenang Bhangale, Tushar Stepanov, Vadim Kharkov, Vladimir Schröder, Markus S. Ramprasad, Vedam Tom, Jennifer Durinck, Steffen Bei, Qixin Li, Jiani Guillory, Joseph Phalkek Sameer Basu, Analabha Stinson, Jeremy Nair, Sandhya Malaichamy, Sivasankar Biswas, Nidhan K. Chambers, John C. Cheng, Keith C George, Joyner T. Khor, Seik Soon Kim, Jong-Il Cho, Belong Menon, Ramesh Sattibabu, Thiramsett Bassi, Akshi Deshmukh, Manjari Verma, Anjali Gopalan, Vivek Shin, Jong-Yeon Pratapneni, Mahesh Santhosh, Sam Tokunaga, Katsushi Badrul M. Md-Zain Chan, Kok Gan Parani, Madasamy Natarajan, Purushothaman Hauser, Michael Allingham, R. Rand Santiago-Turla, Ghosh, Arkasubhra Gadde, Santosh Gopi Krishna Fuchsberger, Christian Forer, Lukas Schoenherr, Sebastian Sudoyo, Herawati Lansing, J. Stephen Friedlaender, Jonathan Koki, George Cox, Murray P. Hammer, Michael Karafet, Tatiana Ang, Khai C. Syed Q. Mehdi Radha, Venkatesan Mohan, Viswanathan Majumder, Partha P Seshagiri, Somasekar Seo, Jeong-Sun Schuster, Stephan C. Peterson, Andrew S. |
Keywords: | Science::Medicine | Issue Date: | 2019 | Source: | Wall, J. D., Stawiski, E. W., Ratan, A., Kim, H. L., Kim, C., Gupta, R., . . . Peterson, A. S. (2019). The GenomeAsia 100K Project enables genetic discoveries across Asia. Nature, 576(7785), 106-111. doi:10.1038/s41586-019-1793-z | Journal: | Nature | Abstract: | The underrepresentation of non-Europeans in human genetic studies so far has limited the diversity of individuals in genomic datasets and led to reduced medical relevance for a large proportion of the world’s population. Population-specific reference genome datasets as well as genome-wide association studies in diverse populations are needed to address this issue. Here we describe the pilot phase of the GenomeAsia 100K Project. This includes a whole-genome sequencing reference dataset from 1,739 individuals of 219 population groups and 64 countries across Asia. We catalogue genetic variation, population structure, disease associations and founder effects. We also explore the use of this dataset in imputation, to facilitate genetic studies in populations across Asia and worldwide. | URI: | https://hdl.handle.net/10356/142742 | ISSN: | 0028-0836 | DOI: | 10.1038/s41586-019-1793-z | Rights: | © 2019 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
| Appears in Collections: | ASE Journal Articles |
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| The GenomeAsia 100K Project enables genetic discoveries across Asia.pdf | 2.75 MB | Adobe PDF | View/Open |
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