Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/142861
Full metadata record
DC FieldValueLanguage
dc.contributor.authorNasrollahi, Fatemehen_US
dc.contributor.authorSana, Barindraen_US
dc.contributor.authorParamelle, Daviden_US
dc.contributor.authorAhadian, Samaden_US
dc.contributor.authorKhademhosseini, Alien_US
dc.contributor.authorLim, Sierinen_US
dc.date.accessioned2020-07-06T04:24:13Z-
dc.date.available2020-07-06T04:24:13Z-
dc.date.issued2020-
dc.identifier.citationNasrollahi, F., Sana, B., Paramelle, D., Ahadian, S., Khademhosseini, A., & Lim, S. (2020). Incorporation of graphene quantum dots, iron, and doxorubicin in/on ferritin nanocages for bimodal imaging and drug delivery. Advanced Therapeutics, 3(3), 1900183-. doi:10.1002/adtp.201900183en_US
dc.identifier.issn2366-3987en_US
dc.identifier.urihttps://hdl.handle.net/10356/142861-
dc.description.abstractGraphene quantum dots (GQDs) have been emerging as next‐generation bioimaging agents because of their intrinsic strong fluorescence, photostability, aqueous stability, biocompatibility, and facile synthesis. In this work, GQDs are encapsulated in ferritin protein nanocages to develop multi‐functional nanoplatforms toward multi‐modal imaging and cancer therapy. Encapsulation of ultra‐small GQDs is expected to reduce their quick excretion from the body and increase their bioimaging efficiency. To expand the functionality of protein nanocages as multi‐modal imaging nanoprobes capable of both fluorescence and magnetic resonance imaging (MRI), GQDs and iron are encapsulated inside the core of AfFtn‐AA (an engineered ferritin nanocage derived from the archaeon Archaeoglobus fulgidus ). The co‐encapsulation is achieved through an iron‐mediated, self‐assembly of ferritin dimers resulting in the formation of GQD–iron complex in the ferritin nanocages ((GQDs/Fe)AA). The (GQDs/Fe)AA shows high relaxivities in MRI and pH‐sensitive fluorescence with strong fluorescence at low pH values and on MDA‐MB‐231 cells. As an imaging agent and a drug nanocarrier, (GQDs/Fe)AA exhibits negligible cytotoxicity on the cells and a high loading capacity (35%) of doxorubicin. Taken together, the (GQDs/Fe)AA shows promising applications in cancer diagnosis and therapy as a pH‐responsive fluorophore, MRI agent, and drug nanocarrier.en_US
dc.language.isoenen_US
dc.relation.ispartofAdvanced Therapeuticsen_US
dc.rightsThis is the accepted version of the following article: Nasrollahi, F., Sana, B., Paramelle, D., Ahadian, S., Khademhosseini, A., & Lim, S. (2020). Incorporation of graphene quantum dots, iron, and doxorubicin in/on ferritin nanocages for bimodal imaging and drug delivery. Advanced Therapeutics, 3(3), 1900183-, which has been published in final form at https://doi.org/10.1002/adtp.201900183. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [https://authorservices.wiley.com/authorresources/Journal-Authors/licensing/self-archiving.html].en_US
dc.subjectEngineering::Chemical engineeringen_US
dc.titleIncorporation of graphene quantum dots, iron, and doxorubicin in/on ferritin nanocages for bimodal imaging and drug deliveryen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.organizationp53 Laboratory, A*STARen_US
dc.contributor.organizationNTU-Northwestern Institute for Nanomedicineen_US
dc.identifier.doi10.1002/adtp.201900183-
dc.description.versionAccepted versionen_US
dc.identifier.issue3en_US
dc.identifier.volume3en_US
dc.subject.keywordsFluorescence Imagingen_US
dc.subject.keywordsGraphene Quantum Doten_US
item.fulltextWith Fulltext-
item.grantfulltextopen-
Appears in Collections:SCBE Journal Articles

Web of ScienceTM
Citations 10

25
Updated on Oct 31, 2023

Page view(s)

307
Updated on Mar 28, 2024

Download(s) 50

167
Updated on Mar 28, 2024

Google ScholarTM

Check

Altmetric


Plumx

Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.