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|Title:||Developing the catalytic asymmetric hydroarsination reaction||Authors:||Tay, Wee Shan||Keywords:||Science::Chemistry::Organic chemistry::Organometallic compounds||Issue Date:||2020||Publisher:||Nanyang Technological University||Source:||Tay, W. S (2020). Developing the catalytic asymmetric hydroarsination reaction. Doctoral thesis, Nanyang Technological University, Singapore.||Abstract:||The asymmetric hydroarsination reaction is arguably the most atom-economical and efficient manner to produce chiral arsines with high enantiopurities. Although various catalysts have been developed for the analogous hydrophosphination reaction, none have been effective for the hydroarsination reaction thus far. Herein, the development of organometallic (Pd- and Ni- based) and organic (phosphine-based) catalytic systems for the hydroarsination reaction is discussed. Mechanistic investigations reveal that arsines were not direct substitutes of phosphines in this instance. Consequently, arsines were applied in several novel applications such as in deuteration, decomplexation and as a directing group. The relevance of these developments to general synthetic chemistry is also outlined.||URI:||https://hdl.handle.net/10356/142898||Rights:||This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||SPMS Theses|
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