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dc.contributor.authorShah, Ankur Harishen_US
dc.contributor.authorPokholenko, Oleksanderen_US
dc.contributor.authorNanda, Himanshu Sekharen_US
dc.contributor.authorSteele, Terry W. J.en_US
dc.identifier.citationShah, A. H., Pokholenko, O., Nanda, H. S., & Steele, T. W. J. (2019). Non-aqueous, tissue compliant carbene-crosslinking bioadhesives. Materials Science and Engineering: C, 100, 215-225. doi:10.1016/j.msec.2019.03.001en_US
dc.description.abstractSurgical adhesives are an attractive alternative to traditional mechanical tissue fixation methods of sutures and staples. Ease of application, biocompatibility, enhanced functionality (drug delivery) are known advantages but weak adhesion strength in the wet environment and lack of tissue compliant behavior still pose a challenge. In order to address these issues, non-aqueous bioadhesive based on blends of polyamidoamine (PAMAM) dendrimer, conjugated with 4-[3-(trifluoromethyl)-3H-diazirin-3-yl] benzyl bromide (PAMAM-g-diazirine) and liquid polyethylene glycol (PEG 400) has been developed. PEG 400 biocompatible solvent reduces the viscosity of PAMAM-g-diazirine dendrimer without incorporating aqueous solvents or plasticizers, allowing application by syringe or spray. Upon UV activation, diazirine-generated reactive intermediates lead to intermolecular dendrimer crosslinking. The properties of the crosslinked matrix are tissue compliant, with anisotropic material properties dependent on the PEG 400 wt%, UV dose, pressure and uncured adhesive thickness. The hygroscopic PAMAM-g-diazirine/PEG 400 blend was hypothesized to absorb water at the tissue interface, leading to high interfacial adhesion, however porous matrices led to cohesive failure. The hydrophilic nature of the polyether backbone (PEG 400) shielded cationic PAMAM dendrimers with cured bioadhesive film displaying significantly less platelet activation than neat PAMAM-g-diazirine or PLGA thin films.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.relation.ispartofMaterials Science and Engineering: Cen_US
dc.rights© 2019 Elsevier. All rights reserved. This paper was published in Materials Science and Engineering: C and is made available with permission of Elsevier.en_US
dc.titleNon-aqueous, tissue compliant carbene-crosslinking bioadhesivesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.versionAccepted versionen_US
dc.description.acknowledgementAuthors acknowledge the financial support from the following research grant: Ministry of Education Tier 1 Grant (RG47/16): Coil Expanding Layers (COELS) For Intravascular Repairs; Ministry of Education Tier 2 grant: Tailored soft tissue bioadhesive for site specific therapy (MOE2012-T2-2-046). Ministry of Education Tier 2 Grant: Reversible, electrocuring adhesives (MOE2014-T2-2-100).en_US
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