Please use this identifier to cite or link to this item:
|Title:||A self-adhesive microneedle patch with drug loading capability through swelling effect||Authors:||Chew, Sharon Wan Ting
Shah, Ankur Harish
Steele, Terry W. J.
|Keywords:||Engineering::Materials||Issue Date:||2020||Source:||Chew, S. W. T., Shah, A. H., Zheng, M., Chang, H., Wiraja, C., Steele, T. W. J. & Xu, C. (2020). A self-adhesive microneedle patch with drug loading capability through swelling effect. Bioengineering & Translational Medicine, 5(2), e10157. doi:10.1002/btm2.10157||Journal:||Bioengineering & Translational Medicine||Abstract:||Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug-loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post-fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm-2. Additional post-fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies.||URI:||https://hdl.handle.net/10356/143108||ISSN:||2380-6761||DOI:||10.1002/btm2.10157||Rights:||© 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers.||Fulltext Permission:||open||Fulltext Availability:||With Fulltext|
|Appears in Collections:||MSE Journal Articles|
Files in This Item:
|Self adhesive microneedle patch with drug loading capability.pdf||Open Access Article||3.85 MB||Adobe PDF||View/Open|
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.