Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/143108
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dc.contributor.authorChew, Sharon Wan Tingen_US
dc.contributor.authorShah, Ankur Harishen_US
dc.contributor.authorZheng, Mengjiaen_US
dc.contributor.authorChang, Haoen_US
dc.contributor.authorWiraja, Christianen_US
dc.contributor.authorSteele, Terry W. J.en_US
dc.contributor.authorXu, Chenjieen_US
dc.date.accessioned2020-08-03T06:17:13Z-
dc.date.available2020-08-03T06:17:13Z-
dc.date.issued2020-
dc.identifier.citationChew, S. W. T., Shah, A. H., Zheng, M., Chang, H., Wiraja, C., Steele, T. W. J. & Xu, C. (2020). A self-adhesive microneedle patch with drug loading capability through swelling effect. Bioengineering & Translational Medicine, 5(2), e10157. doi:10.1002/btm2.10157en_US
dc.identifier.issn2380-6761en_US
dc.identifier.urihttps://hdl.handle.net/10356/143108-
dc.description.abstractMicroneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug-loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post-fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm-2. Additional post-fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies.en_US
dc.description.sponsorshipAgency for Science, Technology and Research (A*STAR)en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relation.ispartofBioengineering & Translational Medicineen_US
dc.rights© 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers.en_US
dc.subjectEngineering::Materialsen_US
dc.titleA self-adhesive microneedle patch with drug loading capability through swelling effecten_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.identifier.doi10.1002/btm2.10157-
dc.description.versionPublished versionen_US
dc.identifier.pmid32440562-
dc.identifier.scopus2-s2.0-85085630539-
dc.identifier.issue2en_US
dc.identifier.volume5en_US
dc.identifier.spagee10157en_US
dc.subject.keywordsBioadhesiveen_US
dc.subject.keywordsDendrimeren_US
dc.description.acknowledgementThis work was supported by Singapore MOE Academic Research Fund (AcRF) Tier 1 grant (RG49/18), Additive Manufacturing for Biological Materials (AMBM) Program (A18A8b0059 to XCJ) from Singapore A*STAR Science and Engineering Research Council (SERC).en_US
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