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Title: A self-adhesive microneedle patch with drug loading capability through swelling effect
Authors: Chew, Sharon Wan Ting
Shah, Ankur Harish
Zheng, Mengjia
Chang, Hao
Wiraja, Christian
Steele, Terry W. J.
Xu, Chenjie
Keywords: Engineering::Materials
Issue Date: 2020
Source: Chew, S. W. T., Shah, A. H., Zheng, M., Chang, H., Wiraja, C., Steele, T. W. J. & Xu, C. (2020). A self-adhesive microneedle patch with drug loading capability through swelling effect. Bioengineering & Translational Medicine, 5(2), e10157. doi:10.1002/btm2.10157
Journal: Bioengineering & Translational Medicine 
Abstract: Microneedles (MNs) offer a rapid method of transdermal drug delivery through penetration of the stratum corneum. However, commercial translation has been limited by fabrication techniques unique to each drug. Herein, a broadly applicable platform is explored by drug-loading via swelling effect of a hydrogel MN patch. A range of small molecule hydrophilic, hydrophobic, and biomacromolecule therapeutics demonstrate successful loading and burst release from hydrogel MNs fabricated from methacrylated hyaluronic acid (MeHA). The post-fabrication drug loading process allows MeHA MN patches with drug loadings of 10 μg cm-2. Additional post-fabrication processes are explored with dendrimer bioadhesives that increase work of adhesion, ensuring stable fixation on skin, and allow for additional drug loading strategies.
ISSN: 2380-6761
DOI: 10.1002/btm2.10157
Schools: School of Chemical and Biomedical Engineering 
School of Materials Science and Engineering 
Rights: © 2020 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals, Inc. on behalf of The American Institute of Chemical Engineers.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:MSE Journal Articles

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