Please use this identifier to cite or link to this item:
https://hdl.handle.net/10356/143111
Title: | Tertiary blends of PAMAM/PEG/PEG tissue bioadhesives | Authors: | Shah, Ankur Harish Djordjevic, Ivan Steele, Terry W. J. |
Keywords: | Engineering::Materials | Issue Date: | 2020 | Source: | Shah, A. H., Djordjevic, I., & Steele, T. W. J. (2020). Tertiary blends of PAMAM/PEG/PEG tissue bioadhesives. Journal of the Mechanical Behavior of Biomedical Materials, 101, 103405. doi:10.1016/j.jmbbm.2019.103405 | Journal: | Journal of the Mechanical Behavior of Biomedical Materials | Abstract: | Lack of wet adhesion and biomechanical mismatch at tissue interfaces are the major challenges related to surgical adhesive formulations. Carbene-based bioadhesives seek to address those limitations, due to their ability to covalently bond to wet tissue surfaces. Herein, diazirine-grafted polyamidoamine (PAMAM) dendrimers (PDz) dissolved in various liquid polyethylene glycols (PEG) are reported. Non-aqueous liquid PEG 400 reinforced with high molecular weight PEGs (2 kDa, 6 kDA and 10 kDa) dissolved PDz to form tertiary blends for optimization of viscosity and shear storage modulus. Dynamic photorheometry correlated PEG molar mass and tertiary ratios to adhesion strength, swelling-in-water profile and potential weight loss in aqueous medium. Tertiary blended adhesives demonstrate an improvement in elongation and adhesion strength compared to the binary blends used as control. | URI: | https://hdl.handle.net/10356/143111 | ISSN: | 1878-0180 | DOI: | 10.1016/j.jmbbm.2019.103405 | Rights: | © 2020 Elsevier. All rights reserved. This paper was published in Journal of the Mechanical Behavior of Biomedical Materials and is made available with permission of Elsevier. | Fulltext Permission: | open | Fulltext Availability: | With Fulltext |
Appears in Collections: | MSE Journal Articles |
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accepted_manuscript.pdf | 850.79 kB | Adobe PDF | View/Open |
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