Please use this identifier to cite or link to this item: https://hdl.handle.net/10356/143111
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dc.contributor.authorShah, Ankur Harishen_US
dc.contributor.authorDjordjevic, Ivanen_US
dc.contributor.authorSteele, Terry W. J.en_US
dc.date.accessioned2020-08-03T06:58:07Z-
dc.date.available2020-08-03T06:58:07Z-
dc.date.issued2020-
dc.identifier.citationShah, A. H., Djordjevic, I., & Steele, T. W. J. (2020). Tertiary blends of PAMAM/PEG/PEG tissue bioadhesives. Journal of the Mechanical Behavior of Biomedical Materials, 101, 103405. doi:10.1016/j.jmbbm.2019.103405en_US
dc.identifier.issn1878-0180en_US
dc.identifier.urihttps://hdl.handle.net/10356/143111-
dc.description.abstractLack of wet adhesion and biomechanical mismatch at tissue interfaces are the major challenges related to surgical adhesive formulations. Carbene-based bioadhesives seek to address those limitations, due to their ability to covalently bond to wet tissue surfaces. Herein, diazirine-grafted polyamidoamine (PAMAM) dendrimers (PDz) dissolved in various liquid polyethylene glycols (PEG) are reported. Non-aqueous liquid PEG 400 reinforced with high molecular weight PEGs (2 kDa, 6 kDA and 10 kDa) dissolved PDz to form tertiary blends for optimization of viscosity and shear storage modulus. Dynamic photorheometry correlated PEG molar mass and tertiary ratios to adhesion strength, swelling-in-water profile and potential weight loss in aqueous medium. Tertiary blended adhesives demonstrate an improvement in elongation and adhesion strength compared to the binary blends used as control.en_US
dc.description.sponsorshipMinistry of Education (MOE)en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of the Mechanical Behavior of Biomedical Materialsen_US
dc.rights© 2020 Elsevier. All rights reserved. This paper was published in Journal of the Mechanical Behavior of Biomedical Materials and is made available with permission of Elsevier.en_US
dc.subjectEngineering::Materialsen_US
dc.titleTertiary blends of PAMAM/PEG/PEG tissue bioadhesivesen_US
dc.typeJournal Articleen
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.identifier.doi10.1016/j.jmbbm.2019.103405-
dc.description.versionAccepted versionen_US
dc.identifier.pmid31539737-
dc.identifier.scopus2-s2.0-85072218814-
dc.identifier.volume101en_US
dc.identifier.spage103405en_US
dc.subject.keywordsBioadhesiveen_US
dc.subject.keywordsCarbeneen_US
dc.description.acknowledgementAuthors acknowledge the financial support from the following research grant: Ministry of Education Tier 1 Grant (RG47/16): Coil Expanding Layers (COELS) For Intravascular Repairs; Ministry of Education Tier 2 grant: Tailored soft tissue bioadhesive for site-specific therapy (MOE2012-T2-2-046).en_US
item.grantfulltextembargo_20221231-
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