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Title: Modeling of a fast-response magnetic-sensitive hydrogel for dynamic control of microfluidic flow
Authors: Liu, Qimin
Li, Hua
Lam, Khin Yong
Keywords: Engineering::Mechanical engineering
Issue Date: 2018
Source: Liu, Q., Li, H., & Lam, K. Y. (2019). Modeling of a fast-response magnetic-sensitive hydrogel for dynamic control of microfluidic flow. Physical Chemistry Chemical Physics, 21(4), 1852-1862. doi:10.1039/c8cp06556j
Journal: Physical Chemistry Chemical Physics
Abstract: A magnetic-sensitive hydrogel-based microfluidic system is designed via a magneto-chemo-hydro-mechanical model for replicating various physiological and pathological conditions in the human body, by which the desired flow patterns can be generated in real time due to the fast-response deformation of the magnetic hydrogel. In the model, the fluid-structure interaction is characterized between the deformable magnetic hydrogel and surrounding fluid flow through the fully coupled arbitrary Lagrangian-Eulerian (ALE) method. Moreover, the physicochemical mechanisms including hydrogel magnetization, fluid diffusion, fluid flow, and hydrogel large deformation are characterized. After validation of the present model with both the finite difference and experimental results in the open literature, the transient behavior of the magnetic hydrogel is investigated, and the results show that the response time for the magnetic hydrogel is improved significantly in a uniform magnetic field compared with that of a hydrogel without the magnetic effect. Furthermore, various patterns of pulsatile flow are generated for mimicking the cell physiological microenvironment experienced by bone marrow stromal cells, and also for the pathological condition at the femoral artery during diastole and systole, respectively. Therefore, the present magnetic-sensitive hydrogel-based microfluidic system via the multiphysics model may provide a relevant humanized manipulation platform to investigate cell behavior and function through microfluidic chips.
ISSN: 1463-9076
DOI: 10.1039/c8cp06556j
Schools: School of Mechanical and Aerospace Engineering 
Rights: © 2019 the Owner Societies. All rights reserved. This paper was published by Royal Society of Chemistry in Physical Chemistry Chemical Physics and is made available with permission of the Owner Societies.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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