Please use this identifier to cite or link to this item:
|Title:||Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups||Authors:||Aishah Ismail
Bhatti, Mehwish S.
Lu, Cheng Kai
Tang, Tong Boon
|Keywords:||Science::Medicine||Issue Date:||2018||Source:||Aishah Ismail, Bhatti, M. S., Faye, I., Lu, C. K., Laude, A., & Tang, T. B. (2018). Pulse waveform analysis on temporal changes in ocular blood flow due to caffeine intake : a comparative study between habitual and non-habitual groups. Graefe's Archive for Clinical and Experimental Ophthalmology, 256(9), 1711-1721. doi:10.1007/s00417-018-4030-9||Journal:||Graefe's archive for clinical and experimental ophthalmology||Abstract:||Purpose To evaluate and compare the temporal changes in pulse waveform parameters of ocular blood flow (OBF) between nonhabitual and habitual groups due to caffeine intake. Method This study was conducted on 19 healthy subjects (non-habitual 8; habitual 11), non-smoking and between 21 and 30 years of age. Using laser speckle flowgraphy (LSFG), three areas of optical nerve head were analyzed which are vessel, tissue, and overall, each with ten pulse waveform parameters, namely mean blur rate (MBR), fluctuation, skew, blowout score (BOS), blowout time (BOT), rising rate, falling rate, flow acceleration index (FAI), acceleration time index (ATI), and resistive index (RI). Two-way mixed ANOVA was used to determine the difference between every two groups where p < 0.05 is considered significant. Result There were significant differences between the two groups in several ocular pulse waveform parameters, namely MBR (overall, vessel, tissue), BOT (overall), rising rate (overall), and falling rate (vessel), all with p < 0.05. In addition, the ocular pulse waveform parameters, i.e., MBR (overall), skew (tissue), and BOT (tissue) showed significant temporal changes within the nonhabitual group, but not within the habitual group. The temporal changes in parameters MBR (vessel, tissue), skew (overall, vessel), BOT (overall, vessel), rising rate (overall), falling rate (overall, vessel), and FAI (tissue) were significant for both groups (habitual and non-habitual) in response to caffeine intake. Conclusion The experiment results demonstrated caffeine does modulate OBF significantly and response differently in nonhabitual and habitual groups. Among all ten parameters, MBR and BOT were identified as the suitable biomarkers to differentiate between the two groups.||URI:||https://hdl.handle.net/10356/143144||ISSN:||0721-832X||DOI:||10.1007/s00417-018-4030-9||Rights:||© 2018 Springer-Verlag GmbH Germany, part of Springer Nature. All rights reserved.||Fulltext Permission:||none||Fulltext Availability:||No Fulltext|
|Appears in Collections:||LKCMedicine Journal Articles|
Updated on Mar 10, 2021
Updated on Mar 3, 2021
Updated on May 15, 2022
Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.