Please use this identifier to cite or link to this item:
Title: Oxytocin receptor gene and parental bonding modulate prefrontal responses to cries : a NIRS study
Authors: Cataldo, Ilaria
Neoh, Michelle Jin-Yee
Chew, Wei Fang
Foo, Jia Nee
Lepri, Bruno
Esposito, Gianluca
Keywords: Social sciences::Psychology
Issue Date: 2020
Source: Cataldo, I., Neoh, M. J.-Y., Chew, W. F., Foo, J. N., Lepri, B., & Esposito, G. (2020). Oxytocin receptor gene and parental bonding modulate prefrontal responses to cries : a NIRS Study. Scientific Reports, 10(1),8588-. doi:10.1038/s41598-020-65582-0
Project: M4081597 (G.E.)
RG55/18 (NS) 2018-T1-001-172 (G.E.)
Journal: Scientific Reports 
Abstract: The ability to interpret and regulate emotions relies on experiences of emotional socialization, obtained firstly through the interaction with the parents, and on genetic features that affect how individuals take on social situations. Evidence from the genetic field states that specific allelic variations of the oxytocin receptor gene polymorphisms regulate physiological modulation of human behavior, especially concerning responses to social cues and affiliative behaviors. Starting from this gene-by-environment interaction frame, we assessed 102 young adults for OXTr rs53576 and rs2254298, recalled parental bonding (using the Parental Bonding Instrument), and recorded participants' neural responses to social stressors using Near InfraRed Spectroscopy (NIRS). The results highlight that higher genetic susceptibility (G/G homozygous) to familiar context and positive early life interactions modulate more optimal neural responses to general social cues, in terms of promptness to action. With regards to the dimensions of parental bonding, we found lateralized effects, with greater activation in the right prefrontal cortex for Care subscales, and on the left side of the prefrontal cortex for Overprotection. Results provide evidence to understand the neurological mechanisms behind the negative impact of poor parenting practices on the child.
ISSN: 2045-2322
DOI: 10.1038/s41598-020-65582-0
Rights: © 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SSS Journal Articles


Updated on Jan 15, 2021


Updated on Jan 12, 2021

Page view(s)

Updated on Jan 17, 2021


Updated on Jan 17, 2021

Google ScholarTM




Items in DR-NTU are protected by copyright, with all rights reserved, unless otherwise indicated.