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Title: The biocompatibility studies of polymer dots on pregnant mice and fetuses
Authors: Wu, Na
Zhang, Zheng
Zhou, Jie
Sun, Zezhou
Deng, Yueyue
Lin, Guimiao
Ying, Ming
Wang, Xiaomei
Yong, Ken-Tye
Wu, Changfeng
Xu, Gaixia
Keywords: Engineering::Electrical and electronic engineering
Issue Date: 2017
Source: Wu, N., Zhang, Z., Zhou, J., Sun, Z., Deng, Y., Lin, G., ... Xu, G. (2017). The biocompatibility studies of polymer dots on pregnant mice and fetuses. Nanotheranostics, 1(3), 261-271. doi:10.7150/ntno.18964
Journal: Nanotheranostics 
Abstract: Semiconducting polymer dots (Pdots) are small nanoparticles consisting primarily of fluorescent pi-conjugated polymers which show superior optical properties for biological imaging and biosensors. It is necessary to explore systematically the toxicity of Pdots on animals before extensive biomedical applications. The reproductive system is very sensitive to the external invasion and essential for species reproduction as well. In this work, we used the pregnant mice to investigate the reproductive toxicity of Pdots. The changes in body weight of each maternal mouse were recorded every two days. The main organs were collected and analyzed as soon as all the pregnant mice were sacrificed on the 15th embryonic day. Distributions of Pdots on maternal major organs and tissues were examined in frozen tissue sections. Hematoxylin and eosin (H&E) staining was performed to investigate the histopathological changes of maternal organs. The blood chemistry test was applied to study the effects of Pdots on organ functions. Female hormones were evaluated by immunoassays. The amniotic fluid was inspected for assessing their penetration ability of Pdots. Levels of placenta growth related factors were detected by RT-PCR to evaluate the function of placenta. These results showed that Pdots were mainly accumulated in liver and spleen, and no apparent impact was observed on maternal body weight and organs coefficients. Histopathological images also showed normal tissue morphology compared with the untreated group. The female hormones levels did not show significant difference among the three groups as well. Trace amount of Pdots could get into the amniotic fluid but did not change the placental functions and the early development of fetus. Our results demonstrated that Pdots have excellent biocompatibility and no reproductive toxicity under the dosages used in this work, which means that Pdots have great potential in preclinical applications in the future.
ISSN: 2206-7418
DOI: 10.7150/ntno.18964
Rights: © 2017 Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license ( See for full terms and conditions.
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:EEE Journal Articles

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