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Title: Microchemical plant in a liquid droplet : plasmonic liquid marble for sequential reactions and attomole detection of toxin at microliter scale
Authors: Han, Xuemei
Koh, Charlynn Sher Lin
Lee, Hiang Kwee
Chew, Wee Shern
Ling, Xing Yi
Keywords: Science::Physics
Issue Date: 2017
Source: Han, X., Koh, C. S. L., Lee, H. K., Chew, W. S., & Ling, X. Y. (2017). Microchemical plant in a liquid droplet : plasmonic liquid marble for sequential reactions and attomole detection of toxin at microliter scale. ACS Applied Materials & Interfaces, 9(45), 39635-39640. doi:10.1021/acsami.7b13917
Journal: ACS Applied Materials & Interfaces
Abstract: Miniaturizing the continuous multistep operations of a factory into a microchemical plant offers a safe and cost-effective approach to promote high-throughput screening in drug development and enforcement of industrial/environmental safety. While particle-assembled microdroplets in the form of liquid marble are ideal as microchemical plant, these platforms are mainly restricted to single-step reactions and limited to ex situ reaction monitoring. Herein, we utilize plasmonic liquid marble (PLM), formed by encapsulating liquid droplet with Ag nanocubes, to address these issues and demonstrate it as an ideal microchemical plant to conduct reaction-and-detection sequences on-demand in a nondisruptive manner. Utilizing a two-step azo-dye formation as our model reaction, our microchemical plant allows rapid and efficient diazotization of nitroaniline to form diazonium nitrobenzene, followed by the azo coupling of this intermediate with target aromatic compound to yield azo-dye. These molecular events are tracked in situ via SERS measurement through the plasmonic shell and further verified with in silico investigation. Furthermore, we apply our microchemical plant for ultrasensitive SERS detection and quantification of bisphenol A (BPA) with detection limit down to 10 amol, which is 50 000-fold lower than the BPA safety limit. Together with the protections offered by plasmonic shell against external environments, these collective advantages empower PLM as a multifunctional microchemical plant to facilitate small-volume testing and optimization of processes relevant in industrial and research contexts.
ISSN: 1944-8244
DOI: 10.1021/acsami.7b13917
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:SPMS Journal Articles


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