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Title: One-step synthesis of cyclodextrin-capped gold nanoparticles for ultra-sensitive and highly-integrated plasmonic biosensors
Authors: Zhang, Nancy Meng Ying
Qi, Miao
Wang, Zhixun
Wang, Zhe
Chen, Mengxiao
Li, Kaiwei
Shum, Ping
Wei, Lei
Keywords: Engineering::Electrical and electronic engineering
Issue Date: 2019
Source: Zhang, N. M. Y., Qi, M., Wang, Z., Wang, Z., Chen, M., Li, K., ... Wei, L. (2019). One-step synthesis of cyclodextrin-capped gold nanoparticles for ultra-sensitive and highly-integrated plasmonic biosensors. Sensors and Actuators B: Chemical, 286, 429-436. doi:10.1016/j.snb.2019.01.166
Journal: Sensors and Actuators B: Chemical
Abstract: Plasmonics in conjunction with supramolecular chemistry brings new opportunities for biosensing. Modified with macrocyclic supramolecules, noble metal nanoparticles possess improved biocompatibility and highly efficient biomolecule immobilization and recognition via host-guest interaction. In this work, we synthesize high-quality and monodisperse β-cyclodextrin-capped gold nanoparticles (β-CD-capped AuNPs) in one-step facile and eco-friendly process, where β-CD functions as both reducing and capping agent. Integrated with a microfiber, the β-CD-capped AuNPs deliver promising localized surface plasmon resonance properties and ultralow detection limit of cholesterol molecules of 5 aM. The selective recognition of our proposed biosensor to cholesterol is further verified by interference study and analysis of real human serum samples. This study shows the bright prospects of supramolecular chemistry assisted plasmonics in achieving highly integrated and highly sensitive biosensing with extremely low consumption of clinical samples and small footprint.
ISSN: 0925-4005
DOI: 10.1016/j.snb.2019.01.166
Rights: © 2019 Elsevier B.V. All rights reserved. This paper was published in Sensors and Actuators B: Chemical and is made available with permission of Elsevier B.V.
Fulltext Permission: open
Fulltext Availability: With Fulltext
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