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Title: Peripheral biomarkers for early detection of Alzheimer's and Parkinson's diseases
Authors: Htike, Thein Than
Mishra, Sachin
Kumar, Sundramurthy
Padmanabhan, Parasuraman
Gulyás, Balázs
Keywords: Science::Medicine
Issue Date: 2018
Source: Htike, T. T., Mishra, S., Kumar, S., Padmanabhan, P., & Gulyás, B. (2019). Peripheral biomarkers for early detection of Alzheimer’s and Parkinson’s diseases. Molecular Neurobiology, 56(3), 2256-2277. doi:10.1007/s12035-018-1151-4
Journal: Molecular Neurobiology 
Abstract: Neurological disorders are found to be influencing the peripheral tissues outside CNS. Recent developments in biomarkers for CNS have emerged with various diagnostic and therapeutic shortcomings. The role of central biomarkers including CSF-based and molecular imaging-based probes are still unclear for early diagnosis of major neurological diseases. Current trends show that early detection of neurodegenerative diseases with non-invasive methods is a major focus of researchers, and the development of biomarkers aiming peripheral tissues is in demand. Alzheimer's and Parkinson's diseases are known for the progressive loss in neural structures or functions, including the neural death. Various dysfunctions of metabolic and biochemical pathways are associated with early occurrence of neuro-disorders in peripheral tissues including skin, blood cells, and eyes. This article reviews the peripheral biomarkers explored for early detection of Alzheimer's and Parkinson's diseases including blood cells, skin fibroblast, proteomics, saliva, olfactory, stomach and colon, heart and peripheral nervous system, and others.
ISSN: 0893-7648
DOI: 10.1007/s12035-018-1151-4
Rights: © 2019 Springer Science+Business Media. This is a post-peer-review, pre-copyedit version of an article published in Molecular Neurobiology. The final authenticated version is available online at:
Fulltext Permission: open
Fulltext Availability: With Fulltext
Appears in Collections:LKCMedicine Journal Articles

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